疱疹患者40例临床特征分析及疱液病毒载量的实验鉴别  被引量:2

Clinical characteristics analysis and virus load identification of blister fluid in forty patients with herpes

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作  者:孟晓文[1] 陈文佳[1,2] 王丽娜 张春梅[3] 金晓红[1] Meng Xiaowen;Chen Wenjia;Wang Lina;Zhang Chunmei;Jin Xiaohong(Department of Anesthesiology,First Affiliated Hospital of Soochow University,Suzhou City,Jiangsu Province 215006,China)

机构地区:[1]苏州大学附属第一医院麻醉科,苏州市215006 [2]泰州市人民医院麻醉,泰州市225300 [3]上海交通大学医学院苏州九龙医院皮肤科,苏州市215021

出  处:《实用疼痛学杂志》2018年第4期268-271,共4页Pain Clinic Journal

基  金:国家自然科学基金(81471136,81701098);江苏省青年医学重点人才(QNRC2016740);苏州市民生科技(SYS201738).

摘  要:目的 对急性期疱疹患者40例进行临床特征分析及疱疹液单纯疱疹病毒(HSV)和水痘-带状疱疹病毒(VZV)载量的实验鉴别.方法 选择2015年4月至2015年6月苏州九龙医院皮肤科急性期疱疹患者40例,采用视觉模拟评分法(VAS)进行疼痛评估;采用普通PCR方法对疱疹患者皮损疱液中病毒DNA类型及其载量进行检测,并结合患者的临床特征进行分析.结果 VZV感染的患者为16例,且患者疱疹液中VZV的DNA载量与VAS疼痛评分呈正相关(r=0.58,P=0.018),重度组(VAS评分7~10)疱疹患者疱疹液VZV的DNA载量(9.6±0.7)明显高于中度组患者(VAS评分4~6)VZV的DNA载量(6.7±0.7)以及轻度组患者(VAS评分0~3)VZV的DNA载量(5.5±1.0),且差异有统计学意义(P<0.05),而中度组与轻度组比较差异无统计学意义(P>0.05);所有患者疱疹液标本均未检测到HSV.结论 检测疱疹患者感染病毒类型以及急性期DNA载量的水平,对于确诊VZV感染,评价临床患者病情特征以及治疗效果有重要的参考价值.Objective To analyse the clinical characteristics and identify the virus load of blister fluid in forty patients with herpes in acute phase.Methods Forty patients with acute herpes in department of dermatologry of Suzhou Kowloon Hospital from April 2015 to June 2015 were enrolled the study.Visual analogue scale(VAS)was carried out to assess the degree of pain.Polymerase chain reaction(PCR)method was used to investigate the virus load of VZV and HSV in blister fluid of forty patients with herpes and the relationship was analyzed between virus load and clinical characteristics.Results Sixteen patients with herpes were infected by VZV,and the VZV DNA load of herpes fluid was associated with the VAS(r=0.58,P=0.018).The VZV DNA load(9.6±0.7)in severe group(VAS 7-10)was significantly higher than VZV DNA load(6.7±0.7)in moderate group(VAS 4-6)and VZV DNA load(5.5±1.0)in mild group(VAS 0-3),with significant difference.There was no significant difference between the moderate group and mild group.HSV was not detected in blister fluid of forty patients with herpes.Conclusion Detecting the virus type and DNA load of blister fluid has important reference value for the diagnosis of VZV infection,the evaluation of the clinical characteristics and the therapeutic effect.

关 键 词:疱疹液 水痘-带状疱疹病毒 神经痛 DNA 

分 类 号:R73[医药卫生—肿瘤]

 

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