Efficiency of EBUS-TBNA for diagnosing benign and malignant lymphadenopathy  

作　　者：Yang-Li Liu Xiao-Ran Liu Hui Li Feng-Jia Chen Huai Liao Can-Mao Xie 

机构地区：[1]Division of Respiratory Medicine,The First Affiliated Hospital of Sun Yat-sen University,Zhongshan Road,Guangzhou,Guangdong Province,People's Republic of China [2]Emergency Department,The Affiliated Hospital of Hainan Medical University,Xueyuan Road,Haikou,Hainan Province,People's Republic of China [3]Division of Respiratory Medicine,The Affiliated Nanjing Drum Tower Hospital,Nanjing University Medical School,Nanjing,Jiangsu Province,People's Republic of China

出　　处：《Journal of Acute Disease》2018年第5期197-201,共5页急性病杂志（英文版）

基　　金：grants from the National Science Foundation of China(NSFC)(No.81260010,81460006).

摘　　要：Objective:To determine whether endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) can rapidly distinguish among lung cancer,tuberculosis and sarcodosis,and to explore its sensitivity and specificity.Methods:Clinical data of patients with enlarged mediastinal or hilar lymphadenopathy who underwent EBUS-TBNA at our hospital between September 1,2012 and June 30,2015 for were retrospectively analyzed.The sensitivity,specificity,positive predictive value,and negative predicted value [including 95% confidence interval (CI)] were calculated..Results:A total of 299 lymph nodes from 201 patients underwent EBUS-TBNA were selected and no serious complications occurred.EBUS-TBNA showed a sensitivity of 87.9% (124/141) (95% CI:81%-92%),a specificity of 100.0% (124/124) (95% CI:97%-100%),and a negative predicted value of 41.3% (95% CI:23%-61%) in the detection of lung cancer.The sensitivity and specificity of diagnosis of mediastinal tuberculosis lymphadenitis were 72.4% (21/29) (95% CI:53%-87%) and 100.0% (95% CI:82%-100%);while sensitivity and specificity of diagnosis of sarcoidosis were 71.4% (5/7) (95% CI:29%-96%) and 100.0% (95% CI:91%-100%).Conclusions:The sensitivity and specificity of EBUS-TBNA do not significantly differ for a diagnosis of lung cancer versus tuberculosis or sarcodosis.

关 键 词：EBUS TBNA LYMPHADENOPATHY MALIGNANCY BENIGN disease 

分 类 号：R73[医药卫生—肿瘤]