Effect of papaverine combined with tirofiban intracoronary injection on the degree of myocardial injury in patients with no reflow during PCI  

作　　者：De-Yin Zeng Fei Lu 

机构地区：[1]Cardiology Department No.3,Ankang Central Hospital in Shaanxi Province,Ankang,Shaanxi Province,725000

出　　处：《Journal of Hainan Medical University》2018年第9期27-30,共4页海南医学院学报（英文版）

摘　　要：Objective:To study the effect of papaverine combined with tirofiban intracoronary injection on the degree of myocardial injury in patients with no reflow during percutaneous coronary intervention (PCI).Methods: Patients who underwent PCI in Ankang Central Hospital between March 2014 and May 2017 were retrospectively studied and divided into two groups according to the intravascular drugs they received during PCI, combined group received papaverine combined with tirofiban intracoronary injection and control group received tirofiban intracoronary injection. The changes in myocardial injury indexes, platelet activation indexes and inflammatory molecules were measured before PCI as well as 24 h and 48 h after PCI.Results:Serum CK-MB, cTnI, MYO, IMA, CD62p, GPIIb/IIIa, MIP-1α, sICAM-1 and HMGB-1 levels as well as peripheral blood Lp-PLA2, PAF, P-selectin, ERK and NF-κB fluorescence intensity of both groups 24 h and 48 h after PCI were significantly lower than those before PCI, and serum CK-MB, cTnI, MYO, IMA, CD62p, GPIIb/IIIa, MIP-1α, sICAM-1 and HMGB-1 levels as well as peripheral blood Lp-PLA2, PAF, P-selectin, ERK and NF-κB fluorescence intensity of combined group 24 h and 48 h after PCI were significantly lower than those of control group.Conclusion: papaverine combined with tirofiban intracoronary injection for PCI can reduce the degree of myocardial injury.

关 键 词：PERCUTANEOUS CORONARY intervention PAPAVERINE Tirofiban PLATELET activation INFLAMMATORY response 

分 类 号：R5[医药卫生—内科学]