Emerging trends in early-onset gastric cancer  

作　　者：Xinlin Wang Xianchun Gao Jun Yu Xiaotian Zhang Yongzhan Nie 

机构地区：[1]State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers,Xi’an,Shaanxi 710032,China [2]National Clinical Research Center for Digestive Diseases,Xijing Hospital of Digestive Diseases,Fourth Military Medical University,Xi’an,Shaanxi 710032,China [3]Beijing Key Laboratory of Carcinogenesis and Translational Research,Department of Gastrointestinal Oncology,Peking University Cancer Hospital&Institute,Beijing 100142,China

出　　处：《Chinese Medical Journal》2024年第18期2146-2156,共11页中华医学杂志（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.82202837,81730016,and 81972761)

摘　　要：The incidence of early-onset gastric cancer(EOGC)is consistently increasing,and its etiology is notably complex.This increase may be attributed to distinctive factors that differ from those associated with late-onset gastric cancer(LOGC),including genetic predispositions,dietary factors,gastric microbiota dysbiosis,and screening of high-risk cases.These factors collectively contribute to the onset of cancer.EOGC significantly differs from LOGC in terms of clinicopathological and molecular characteristics.Moreover,multiple differences in prognosis and clinical management also exist.This study aimed to systematically review the latest research advancements in the epidemiological characteristics,etiological factors,clinicopathological and molecular features,prognosis,and treatment modalities of EOGC.

关 键 词：Early-onset gastric cancer EPIDEMIOLOGY ETIOLOGY Clinicopathological features Molecular signaling Prognosis Clinical management 

分 类 号：R735.2[医药卫生—肿瘤]