Non-genetic risk factors of Parkinson’s disease:A large meta-analysis and systematic review  

作　　者：Kangfu Yin Weiming Su Xiaojing Gu Zheng Jiang Qingqing Duan Bei Cao Liyi Chi Yongping Chen 

机构地区：[1]Department of Neurology,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,China [2]Department of Mental Health Center,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,China [3]Department of Neurology,First Affiliated Hospital of Air Force Military Medical University,Xi’an,Shaanxi 710072,China

出　　处：《Chinese Medical Journal》2024年第15期1873-1875,共3页中华医学杂志（英文版）

基　　金：supported by grants from the National Natural Science Fund of Sichuan(No.2022NSFSC0749);the 1·3·5 project for disciplines of excellence-Clinical Research Fund,West China Hospital,Sichuan University(No.2023HXFH032);the Science and Technology Bureau Fund of Sichuan Province(No.2023YFS0269).

摘　　要：To the Editor:In the recent decades,significant global endeavors have been undertaken to investigate the risk factors associated with Parkinson’s disease(PD)and to enhance the evidence on PD prevention.[1]However,the prevailing key issues in this field are the frequent occurrence of inconsistent or contradictory conclusions and the varying levels of credibility,which are primarily due to the diverse study designs employed.Observational prospective studies(OPSs)and ambidirectional cohort studies(ACSs)have fewer sources of bias and confounding factors compared with retrospective studies.[2]Therefore,we conducted a meta-analysis on prospective studies to obtain more robust results.Considering that the majority of genetic mutations or chromosomal abnormalities occur randomly during DNA replication and are challenging to prevent,this meta-analysis aims to investigate non-genetic risk factors for PD.The non-genetic risk factors encompass the aspects such as environment,lifestyle,and socio-economic that are not directly determined by an individual’s genes.[3]These factors may independently influence an individual’s health status or interact with genetic factors.

关 键 词：ANALYSIS FOUNDING prevailing 

分 类 号：R742.5[医药卫生—神经病学与精神病学]