Deriving skeletal muscle cells from adipose-derived stem cells:Current differentiation strategies  

作　　者：Wei Liang Meng Han Huiting Wu Wanwen Dang Xiaoyu Meng Yonghuan Zhen Yang An 

机构地区：[1]Department of Plastic Surgery,Peking University Third Hospital,Beijing 100191,China

出　　处：《Chinese Medical Journal》2024年第12期1498-1500,共3页中华医学杂志（英文版）

基　　金：supported by the National Natural Science Funder of China(No.81873939);the Peking University Medicine Sailing Program for Young Scholars’Scientific&Technological Innovation(NO.BMU2024YFJHPY030);the Postdoctoral Fellowship Program of CPSF(No.GZC20230151)

摘　　要：To the Editor:Adipose-derived stem cells(ASCs)are promising multipotent stem cells for regeneration of skeletal muscle(SM)tissues.[1]However,the low myogenic differentiation ability limits the application.[2]Therefore,it is necessary to summarize the current differentiation strategy to improve the differentiation efficiency.Traditional methods(biochemical induction)and non-traditional strategies(co-culture,biomechanical approaches,and biomaterial utilization)are commonly used for the differentiation of ASCs into myogenic lineages.Although both strategies can effectively induce differentiation of myogenic cells,cellular unhealthy or immature myogenic differentiation status is still the greatest challenge for researcher.Theoretically,the combination of non-traditional methods and traditional methods has the potential to significantly enhance myogenesis of ASCs with remarkable efficacy,however,evidence is currrently insufficient.This review discusses the traditional and non-traditional strategies,as well as several combination motheds of above strategies,for inducing ASCs differentiation into myogenic cells[Figure 1].

关 键 词：SKELETAL FIGURE STRATEGIES 

分 类 号：R62[医药卫生—整形外科]