Molecular Characteristics of Cephalosporin-Resistant Neisseria gonorrhoeae Strains in China:A Retrospective Study  

作　　者：Jin Zhang Xiao-Yu Zhu Jing-Wei Liu Yue-Ping Yin Shao-Chun Chen 

机构地区：[1]Reference Laboratory for STD Control,Hospital for Skin Diseases(Institute of Dermatology),Chinese Academy of Medical Sciences&Peking Union Medical College,Nanjing,Jiangsu 210042,China [2]National Center for STD Control,Chinese Center for Disease Control and Prevention,Nanjing,Jiangsu 210042,China

出　　处：《International Journal of Dermatology and Venereology》2024年第2期78-83,共6页国际皮肤性病学杂志（英文）

基　　金：supported by National Science and Technology Major Project(No.2018ZX10101001-004-003);Jiangsu Provincial high level health personnel"six one project"top talent project(No.LGY2019091)

摘　　要：Objective:An increasing level of antimicrobial resistance to extended-spectrum cephalosporins has been reported,so we conducted this study to investigate the molecular characteristics of cephalosporin resistant Neisseria gonorrhoeae(NG)strains isolated from China Gonococcal Antimicrobial Resistance Surveillance Programme(China-GRSP).Methods:In total,2,038 NG isolates were collected from the China-GRSP between 2015 and 2016.NG multiantigen sequence typing(NG-MAST),multilocus sequence typing(MLST),and NG sequence typing for antimicrobial resistance(NG-STAR)were used to determine characteristics and resistant determinants of cephalosporin-resistant isolates.The results are described as percentages.Results:Seventy-four(3.6%)cephalosporin-resistant isolates were confirmed.MLST_(ST7363)was the most prevalent MLST among cefixime-resistant(CFX-R)isolates,whereas MLST_(ST7365)(n=8)in was the most prevalent sequence type among ceftriaxone-resistant(CRO-R)isolates.CFX-R strains were mainly associated with penA-X(n=27,44.3%),penA-XIII(n=6,9.8%),penA-XVIII(n=5,8.2%),and CRO-R strains were mainly related to penA-XVIII(n=10,25.6%),penA-43(n=9,23.1%),penA-XIII(n=7,17.9%).Conclusion:The main conclusion of this study is that the predominant cephalosporin-resistant clones in China include locally emerged and imported linages.The CFX-R and CRO-R strains are primarily related to penA mutations,and their predominant genotypes are different.With the increase in international travel,tracking high-risk-resistant clones and identifying outbreaks and their associations with epidemiological characteristics are critical to improve public health.

关 键 词：GONORRHEA resistance CEPHALOSPORIN CEFIXIME CEFTRIAXONE 

分 类 号：R759.2[医药卫生—皮肤病学与性病学]