m the Ministry of Agriculture,Nature and Food Quality in the Netherlands(grant number WOT-01-002-03.02);the Medical Research Council(MRC),Biotechnology and Biological Sciences Research Council(BBSRC),and Natural Environmental Research Council(NERC),which are all councils of UK Research and Innovation(grant number MR/W030578/1);from ZonMw(grant number 10570132110004)under the umbrella of the JPIAMR(Joint Programming Initiative on Antimicrobial Resistance)project STRESST.
Background:Antimicrobial resistance(AMR)in livestock and the environment likely contribute to the prevalence of AMR in humans with potential detrimental effects on human health.As such,annual mandatory monitoring of A...
Supported by2023 Central Funds for Guiding Local Science and Technology Development(ZY20230102);Guilin City Scientific Research and Technology Development Plan Project(20220104-4).
[Objectives]To establish a HPLC-MS method for the determination of polymer impurities in cefathiamidine and its preparations.[Methods]Kromasil 100-5 C_(18) column(4.6 mm ×250 mm,5μm)was used for analysis;mobile phas...
supported by National Science and Technology Major Project(No.2018ZX10101001-004-003);Jiangsu Provincial high level health personnel"six one project"top talent project(No.LGY2019091)
Objective:An increasing level of antimicrobial resistance to extended-spectrum cephalosporins has been reported,so we conducted this study to investigate the molecular characteristics of cephalosporin resistant Neisse...
Background Clostridium difficile,rarely found in hospitals,is a bacterium responsible for post-antibiotic diarrhea and Pseudomembranous Colitis(CPM).C.difficile selective pressure represents potential public health pr...
BACKGROUND Appendicitis, the inflammation of the appendix, is the most common abdominal surgical emergency requiring expedient surgical intervention. Extendedspectrum beta-lactamases(ESBLs) are bacterial enzymes that ...
The goal of our research was to compare the pharmacokinetics and evaluate the bioequivalence of two brands of cephradine 500 mg capsules in 24 normal Korean volunteers. The plasma samples were acquired at 13 time poin...
supported by the National Natural Science Foundation of China(31670091 and 31470177)
In filamentous fungi,nitrogen metabolism is repressed by GATA-type zinc finger transcription factors.Nitrogen metabolite repression has been found to affect antibiotic production,but the mechanism is still poorly unde...
The accelerated weight gain in productive animals as a result of feeding antibiotic enriched fodder has been well known for decades. The better energy harvest is the result of modified gut microbiota as a consequence ...
In the present study we had an aim to develop the methods of functionalizing the surface of magnetite nanoparticles with cefotaxime and ceftriaxone antibiotics. The quantitative analysis of the nanostructured cephalos...
A series of sulfenimine cephalosporin derivatives(6a--6t) was designed, synthesized and evaluated for their inhibitory activity against class A β-lactamase(TEM-1) derived from E. coli, and class C β-lactamase (...