Advancing Cefuroxime Axetil through Nanotechnology: Enhancing Its Effectiveness  

作　　者：Amit Yadav Nita Yadav Reetika Rawat Shipra Sharma Tapasvi Gupta Durga Prasad 

机构地区：[1]Shri Ram Murti Smarak College of Engineering&Technology(Pharmacy),Bareilly,Uttar Pradesh 243202,India [2]School of Pharmacy,Suresh Gyan Vihar University,Jaipur,Rajasthan 302017,India

出　　处：《Journal of Bio-X Research》2024年第4期173-181,共9页生物组学研究杂志(英文)

摘　　要：Cefuroxime axetil,a second-generation cephalosporin antibiotic,has long been utilized to treat various bacterial infections.However,recent advances in nanotechnology have provided new directions for enhancing its effectiveness through the development of innovative nanoformulations.Cefuroxime axetil,which is classified as aβ-lactam agent,has a broad spectrum of activity against both gram-positive and gram-negative microorganisms.This drug exists in polymorphous crystalline and amorphous forms,the latter of which exhibits superior bioavailability.This review explores the pharmacokinetic and various pharmacodynamic properties and mechanisms of action of cefuroxime axetil.Moreover,the challenges posed by the drug’s poor aqueous solubility and bioavailability,and the potential of nanoformulations to address these limitations and enhance the therapeutic efficacy of this agent,are discussed.

关 键 词：pharmacokinetic PHARMACODYNAMIC cephalosporin antibiotichas NANOTECHNOLOGY nanoformulations cefuroxime axetil enhancing its effectiveness 

分 类 号：R978.1[医药卫生—药品]