MACROLIDE

作品数：32被引量：76H指数：4
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相关领域：医药卫生理学更多>>
相关作者：夏曦李少丽李建成丁双阳江海洋更多>>
相关机构：中国农业大学首都儿科研究所中国科学院更多>>
相关期刊：《Acta Pharmacologica Sinica》《Chinese Medical Journal》《Advances in Microbiology》《World Journal of Pediatrics》更多>>
相关基金：国家自然科学基金北京市自然科学基金“十一五”国家科技支撑计划The Royal Society更多>>
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Urgent need to address macrolide‑resistant Mycoplasma pneumoniae in pediatric populations:insights from an expert consensus
《World Journal of Pediatrics》2024年第10期981-982,共2页Xiwei Wang Wenwei Tu 
The increasing prevalence of macrolide-resistant Mycoplasma pneumoniae(MRMP)pneumonia in pediatric patients represents a formidable challenge in contemporary clinical practice,particularly in regions such as East Asia...
关键词：INSIGHT approximate RESISTANT 
Expert consensus on the diagnosis and treatment of macrolide-resistant Mycoplasma pneumoniae pneumonia in children被引量：2
《World Journal of Pediatrics》2024年第9期901-914,共14页Ying-Shuo Wang Yun-Lian Zhou Guan-Nan Bai Shu-Xian Li Dan Xu Li-Na Chen Xing Chen Xiao-Yan Dong Hong-Min Fu Zhou Fu Chuang-Li Hao Jian-Guo Hong En-Mei Liu Han-Min Liu Xiao-Xia Lu Zheng-Xiu Luo Lan-Fang Tang Man Tian Yong Yin Xiao-Bo Zhang Jian-Hua Zhang Hai-Lin Zhang De-Yu Zhao Shun-Ying Zhao Guo-Hong Zhu Ying-Xue Zou Quan Lu Yuan-Yuan Zhang Zhi-Min Chen 
supported by the grants from Key R&D Projects of Zhejiang Province(2023C03009 and 2024C03177).
Background Mycoplasma pneumoniae(M.pneumoniae)is a significant contributor to community-acquired pneumonia among children.Since 1968,when a strain of M.pneumoniae resistant to macrolide antibiotics was initially repor...
关键词：CHILD Macrolide-resistant Mycoplasma pneumoniae RECOMMENDATION Diagnosis Treatment 
Carrimycin,a first in-class anti-cancer agent,targets selenoprotein H to induce nucleolar oxidative stress and inhibit ribosome biogenesis被引量：1
《Cancer Pathogenesis and Therapy》2023年第2期111-115,共5页LaYow C.Yu Danielle D.Dang Sophie Zhuang Shuran Chen Zhengping Zhuang Jared S.Rosenblum 
supported in part by the Intramural Program of the NCI and NINDS(National Institutes of Health)and did not receive any specific grant from funding agencies(e.g.,public,commercial,or not-forprofit sectors)outside of the authors'academic institution.
Carrimycin is a synthetic macrolide antibiotic that has been shown to have anti-cancer activity;however,its exact mechanism of action and molecular target were previously unknown.It was recently elucidated that Isoval...
关键词：SELENOPROTEIN Ribosome biogenesis MACROLIDE Cancer Carrimycin 
Mining and fine-tuning sugar uptake system for titer improvement of milbemycins in Streptomyces bingchenggensis被引量：1
《Synthetic and Systems Biotechnology》2020年第3期214-221,共8页Pinjiao Jin Shanshan Li Yanyan Zhang Liyang Chu Hairong He Zhuoxu Dong Wensheng Xiang 
This work was financially supported by National Natural Science Foundation of China(Grant Nos:31772242,31972348,and 31672092).
Dramatic decrease of sugar uptake is a general phenomenon in Streptomyces at stationary phase,when antibiotics are extensively produced.Milbemycins produced by Streptomyces bingchenggensis are a group of valuable macr...
关键词：STREPTOMYCES Sugar uptake system Fine-tuning Titer improvement Milbemycins Macrolide biopesticides 
A Modular Synthesis of Antitumor Macrolide (-)-Lasonolide A被引量：1
《Chinese Journal of Chemistry》2020年第7期725-736,共12页Lin Yang Zuming Lin Kuan Zheng Luyao Kong Ran Hong 
the Drug Innovation Major Project(2018ZX09711001-005);the National Natural Science Foundation of China(91856202);the National Key R&D Program of China(2019YFA09005000);the Strategic Priority Research Program(XDB20000000);the Key Research Program of Frontier Sciences(QYZDYSSWSLH026)of the Chinese Academy of Sciences is highly appreciated.We also thank Jie Sun(SIOC,CAS)for the X-ray analysis.
Lasonolide A was identified as a potent antitumor macrolide towards various cancer cell lines.The two tetrahydropyrans bearing multiple stereogenic centers as well as the polyvene linkage attracted a dozen synthetic r...
关键词：ALDEHYDES LINKAGE REAGENT 
Preliminary Study on Drug Susceptibility Profile and Resistance Mechanisms to Macrolides of Clinical Isolates of Non-tuberculous Mycobacteria from China被引量：4
《Biomedical and Environmental Sciences》2018年第4期290-299,共10页LI Fu LI Gui Lian PANG Hui LIU Hai Can XIAO Tong Yang LI Shuang Jun LUO Qiao JIANG Yi WANG Rui Bai WAN Kang Lin 
supported by the Key Project of the State Key Laboratory for Infectious Disease Prevention and Control[2014SKLID104];the National Key Programs of Mega Infectious Diseases[2013ZX10003002-001]
Objective Macrolide susceptibility and drug resistance mechanisms of clinical non-tuberculous mycobacteria（NTM） isolates were preliminarily investigated for more accurate diagnosis and treatment of the infection in ...
关键词：Non-tuberculous mycobacteria Macrolide Drug resistance 
Pharmacokinetics of Milbemycin Oxime in Dogs Following Its Intravenous and Oral Administration
《Journal of Northeast Agricultural University(English Edition)》2018年第1期47-54,共8页Lu Yi-tong Qi Lian-wen Xu Qian-qian Ding Liang-jun Wang Bo Liu Hai-rui Li Ji-chang 
Supported by Natural Science Fund of Heilongjiang Province(C201424)
The pharmacokinetics of milbemycin oxime was investigated in dogs following oral(per os, PO) and intravenous(IV) administration. Three groups of dogs received milbemycin oxime tablets as a single PO dose equal to 0.25...
关键词：PHARMACOKINETIC MACROLIDE milbemycin oxime oral administration DOG 
Alkaloids from the endophytic fungus Penicillium brefeldianum and their cytotoxic activities被引量：4
《Chinese Chemical Letters》2017年第6期1194-1199,共6页Na Gao Zhi-Chun Shang Pei Yu Jie Luo Kai-Li Jian Ling-Yi Kong Ming-Hua Yang 
funded by the National Natural Science Foundation of China(No.81503218);the Program for Changjiang Scholars and Innovative Research Team in University(No.IRT_15R63);the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD);the Fundamental Research Funds for the Central Universities(No.2016ZZD010)
One new indoloditerpene,6,7-dehydropaxilline（1）,one new indole-diketopiperazine,spirotryprostatin F（2）,and one new 13-membered macrolide,N-demethylmelearoride A（3）,as well as 8 known alkaloids（4-11）,were isola...
关键词：Penicillium brefeldianum Alkaloids Indoloditerpene Indole-diketopiperazine 13-Membered macrolide Cytotoxicities 
Whole Genome Analysis Reveals New Insights into Macrolide Resistance in Mycoplasma pneumoniae被引量：8
《Biomedical and Environmental Sciences》2017年第5期343-350,共8页LI Shao Li SUN Hong Mei ZHU Bao Li LIU Fei ZHAO Han Qing 
supported by the grants from National Nature Science Foundation of China(81601778 and 81672062);the Beijing Natural Science Foundation(7152025);Beijing Talents Fund(2015000021469G192)
Objective Mutations in 23 S rRNA gene are known to be associated with macrolide resistance in Mycoplasma pneumoniae（M. pneumoniae）. However, these mutations alone do not fully explain the high resistance rates in As...
关键词：Mycoplasma pneumoniae Whole-genome sequencing Drug resistance Macrolide-specific efflux pump Efflux pump inhibitors 
Selective Association between Cephalosporin, Quinolone, Macrolide, and Penicillin Antibiotic Consumption and Childhood Obesity in Europe被引量：1
《Health》2015年第10期1306-1314,共9页Gabor Ternak Zs Edel Zs Feiszt J. Szekeres B. Visegrady I. Wittmann 
The accelerated weight gain in productive animals as a result of feeding antibiotic enriched fodder has been well known for decades. The better energy harvest is the result of modified gut microbiota as a consequence ...
关键词：Antibiotic Consumption CEPHALOSPORIN QUINOLONE MACROLIDE PENICILLIN CHILDHOOD OBESITY Adult OBESITY 
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