儿童胃肠道炎性肌纤维母细胞瘤的诊断与治疗  

Diagnosis and treatment of inflammatory myofibroblastic tumor of gastrointestinal tract in children

作　　者：刘登辉[1] 黎明[1] 唐湘莲[1] 黄召[1] 向强兴 周宇翔[1] 李勇[1] Liu Denghui;Li Ming;Tang Xianglian;Huang Zhao;Xiang Qiangxing;Zhou Yuxiang;Li Yong(Department of General Surgery,Hunan Children's Hospital,Changsha 410007,China)

机构地区：[1]湖南省儿童医院普外科,长沙410007

出　　处：《临床小儿外科杂志》2024年第2期178-183,共6页Journal of Clinical Pediatric Surgery

基　　金：湖南省卫生健康委科研计划课题(202104081314);湖南省自然科学基金-面上项目(2023JJ30323)

摘　　要：目的总结儿童胃肠道炎性肌纤维母细胞瘤(inflammatory myofibroblastic tumor,IMT)的临床特征及诊治经验。方法回顾性分析湖南省儿童医院普外科2010年1月至2021年12月收治的11例胃肠道IMT患儿临床资料,男7例,女4例;发病年龄8个月至15岁,收集患儿临床特点、影像学检查、病理学诊断、外科治疗及随访情况等。结果11例主要以腹痛、呕吐、发热、血便及腹部肿物就诊。10例行一期手术完整切除肿瘤,其中1例术后予化疗;1例经活检确诊后未予手术,仅行化疗。11例均病理诊断明确,均获随访(随访时间6~60个月),其中9例治愈,2例带瘤生存(1例于术后2年复发)。结论儿童胃肠道IMT临床少见,手术是首选治疗方法。复发、难治性IMT的治疗亟待进一步积累经验。Objective To summarize the clinical characteristics and treatment experience of gastrointestinal inflammatory myofibroblastic tumor(IMT)in children.Methods From January 2010 to December 2021,retrospective analysis was performed for the relevant clinical data of 11 children of abdominal gastrointestinal IMT.Clinical manifestations,radiographic features,pathological examinations,surgical approaches and follow-up results were recorded.And the related literatures of pediatric abdominal inflammatory myofibroblastic tumors were retrieved.Results There were 7 boys and 4 girls with a median onset age of 56(8-180)months.The major symptoms were abdominal pain,vomiting,fever,bloody stool and abdominal lump.Total resection(n=10)was performed and postoperative chemotherapy(n=1)offered.And one child underwent biopsy plus postoperative chemotherapy.The follow-up period was(6-60)months until December 2022.Nine children were cured and 2 cases survived with tumors.One child recurred at 2 years post-operation.Conclusions The incidence of gastrointestinal IMT in children is rare.Surgery is a preferred option.Proper managements of recurrent and refractory IMT require extensive experiences and further researches.

关 键 词：肿瘤 肌组织 胃肠肿瘤 炎症 诊断 治疗 预后 儿童 

分 类 号：R735[医药卫生—肿瘤]