Dietary intake and serum levels of copper and zinc and risk of hepatocellular carcinoma:A matched case-control study  

作　　者：Xiaozhan Liu Yaojun Zhang Dinuerguli Yishake Yan Luo Zhaoyan Liu Yuming Chen Huilian Zhu Aiping Fang 

机构地区：[1]Guangdong Provincial Key Laboratory of Food,Nutrition and Health,School of Public Health,Sun Yat-sen University,Guangzhou,Guangdong 510080,China [2]State Key Laboratory of Oncology in South China,Sun Yat-sen University Cancer Center,Guangzhou,Guangdong 510060,China

出　　处：《Chinese Medical Journal》2024年第5期596-603,共8页中华医学杂志（英文版）

基　　金：supported by the grants from the National Natural Science Foundation of China(No.81803219);the Natural Science Foundation of Guangdong Province,China(Nos.2022A1515011744,2020A1515110682,and 2018A030310335);the China Postdoctoral Science Foundation(No.2020M683135)

摘　　要：Background:Copper and zinc are involved in the development of multiple malignancies;yet,epidemiological evidence on hepatocellular carcinoma(HCC)is limited.This study aimed to investigate the association between dietary intake and serum levels of copper and zinc with the risk of HCC.Methods:A total of 434 case-control pairs matched for sex and age(±1 year)were included in this study.Cases with newly diagnosed HCC were from the Guangdong Liver Cancer Cohort(GLCC)study,and healthy controls were from the Guangzhou Nutrition and Health Study(GNHS).A semi-quantitative 79-item food frequency questionnaire(FFQ)was used to assess habitual dietary intakes of copper and zinc.Serum levels of copper and zinc were measured by using inductively coupled plasma mass spectrometry.The copper(Cu)/zinc(Zn)ratio was computed by dividing copper levels by zinc levels.Conditional logistic regression models were performed to calculate the odds ratio(OR)and 95%confidence intervals(CI)for per 1 standard deviation increase(per-SD increase)in copper and zinc levels.Results:Higher dietary intake(OR_(per-SD increase)=0.65,95%CI:0.44,0.96,P_(trend)=0.029)and serum levels of zinc(OR_(per-SD increase)=0.11,95%CI:0.04,0.30,P_(trend)<0.001)were both associated with a lower risk of HCC.Subgroup analyses showed that the inverse association was only pronounced in men but not in women(P_(interaction)=0.041 for dietary zinc intake and 0.010 for serum zinc levels).Serum copper levels(OR_(per-SD increase)=2.05,95%CI:1.39,3.03,P_(trend)=0.020)and serum Cu/Zn ratio(OR_(per-SD increase)=6.53,95%CI:2.52,16.92,P_(trend)<0.001)were positively associated with HCC risk,while dietary copper intake and dietary Cu/Zn ratio were not associated with HCC risk.Conclusion:Zinc may be a protective factor for HCC,especially among men,but the effects of copper on HCC risk are not clear.

关 键 词：COPPER ZINC Hepatocellular carcinoma risk Case-control studies Dietary intake SERUM 

分 类 号：R735.7[医药卫生—肿瘤]