Individualized brain mapping for navigated neuromodulation  

作　　者：Chaohong Gao Xia Wu Xinle Cheng Kristoffer Hougaard Madsen Congying Chu Zhengyi Yang Lingzhong Fan 

机构地区：[1]Sino–Danish College,University of Chinese Academy of Sciences,Beijing 100190,China [2]Brainnetome Center,National Laboratory of Pattern Recognition,Institute of Automation,Chinese Academy of Sciences,Beijing 100190,China [3]School of Artificial Intelligence,University of Chinese Academy of Sciences,Beijing 100190,China [4]Department of Applied Mathematics and Computer Science,Technical University of Denmark,Kongens Lyngby 2800,Denmark [5]Danish Research Centre for Magnetic Resonance,Centre for Functional and Diagnostic Imaging and Research,Copenhagen University Hospital Amager and Hvidovre,Hvidovre 2650,Denmark [6]CAS Center for Excellence in Brain Science and Intelligence Technology,Institute of Automation,Chinese Academy of Sciences,Beijing 100190,China [7]School of Health and Life Sciences,University of Health and Rehabilitation Sciences,Qingdao,Shandong 266000,China

出　　处：《Chinese Medical Journal》2024年第5期508-523,共16页中华医学杂志（英文版）

基　　金：partially supported by STI2030-Major Projects(No.2021ZD0200200);the Natural Science Foundation of China(Nos.82072099,91432302,31620103905,and 62250058);the Strategic Priority Research Program of Chinese Academy of Sciences(No.XDB32030200);the National Key Research&Development Program of China(No.2017YFA0105203)

摘　　要：The brain is a complex organ that requires precise mapping to understand its structure and function.Brain atlases provide a powerful tool for studying brain circuits,discovering biological markers for early diagnosis,and developing personalized treatments for neuropsychiatric disorders.Neuromodulation techniques,such as transcranial magnetic stimulation and deep brain stimulation,have revolutionized clinical therapies for neuropsychiatric disorders.However,the lack of fine-scale brain atlases limits the precision and effectiveness of these techniques.Advances in neuroimaging and machine learning techniques have led to the emergence of stereotactic-assisted neurosurgery and navigation systems.Still,the individual variability among patients and the diversity of brain diseases make it necessary to develop personalized solutions.The article provides an overview of recent advances in individualized brain mapping and navigated neuromodulation and discusses the methodological profiles,advantages,disadvantages,and future trends of these techniques.The article concludes by posing open questions about the future development of individualized brain mapping and navigated neuromodulation.

关 键 词：Brain atlas INDIVIDUALIZATION Navigated neuromodulation Multimodal magnetic resonance imaging Transcranial magnetic stimulation Deep brain stimulation 

分 类 号：R741[医药卫生—神经病学与精神病学]