生长激素补充对垂体前叶功能减退症患者肝肺功能的影响  

Effect of growth hormone supplementation on liver and lung function in patients with hypopituitarism

作　　者：茅江峰[1] 徐洪丽 刘兆祥 王曦[1] 于冰青 朱依祎 季文 张君宜 聂敏[1] 伍学焱[1] Mao Jiangfeng;Xu Hongli;Liu Zhaoxiang;Wang Xi;Yu Bingqing;Zhu Yiyi;Ji Wen;Zhang Junyi;Nie Min;Wu Xueyan(Department of Endocrinology,Peking Union Medical College Hospital,Peking Union Medical College,Chinese Academy of Medical Sciences,Beijing 100730,China;Department of Abdominal Oncology,Hubei Cancer Hospital,Huazhong University of Science and Technology,Wuhan 430079,China;Department of Endocrinology,Tsinghua Changgeng Hospital,Beijing 102218,China;Department of Endocrinology,the First Affiliated Hospital of School of Medicine,Zhejiang University,Hangzhou 310003,China)

机构地区：[1]中国医学科学院北京协和医学院北京协和医院内分泌科,北京100730 [2]华中科技大学附属湖北省肿瘤医院腹部肿瘤内科,武汉430079 [3]北京清华长庚医院内分泌科,北京102218 [4]浙江大学医学院附属第一医院内分泌科,杭州310003

出　　处：《中华医学杂志》2024年第6期450-452,共3页National Medical Journal of China

基　　金：国家自然科学基金(81771576、81971375);北京自然科学基金(7212080)

摘　　要：分析垂体前叶功能减退症(HP)合并肝硬化患者的临床特点,探讨生长激素补充对患者肝肺功能的影响。将2016年1月至2022年12月就诊于北京协和医院的HP合并肝硬化的11例患者纳入研究,其中男8例,女3例,年龄[M(Q_(1),Q_(3))]为31(20,37)岁。其中垂体柄中断综合征患者6例,颅咽管瘤切除术后4例,生殖细胞瘤放化疗后患者1例。患者在HP确诊后[M(Q_(1),Q_(3))]7(1,16)年出现肝硬化。有7例并发肝肺综合征(HPS)。有5例患者在加用生长激素后肝肺功能明显改善,动脉血氧分压从(47±11)mmHg(1 mmHg=0.133 kPa)升至(84±12)mmHg。可见HP患者及时补充生长激素可改善脂肪肝、肝硬化、HPS症状,延缓甚至避免肝脏等器官的移植手术。To analyze the clinical features of patients with anterior hypopituitarism(HP)complicated with cirrhosis,and to explore the effects of growth hormone supplementation on liver and lung function.A total of 11 patients with HP complicated with cirrhosis admitted to Peking Union Medical College Hospital from January 2016 to December 2022 were included in the study,including 8 males and 3 females,aged[M(Q_(1),Q_(3))]31(20,37)years.There were 6 patients with pituitary stalk interruption syndrome,4 patients after craniopharyngioma resection,and 1 patient after germinal cell tumor chemoradiotherapy.Cirrhosis appeared at[M(Q_(1),Q_(3))]7(1,16)years after the diagnosis of HP.There were 7 cases complicated with hepatopulmonary syndrome(HPS).The liver and lung function of 5 patients were improved significantly after the addition of growth hormone,and the arterial partial pressure of oxygen increased from(47±11)mmHg(1 mmHg=0.133 kPa)to(84±12)mmHg.Timely supplementation of growth hormone can improve the symptoms of fatty liver,cirrhosis and HPS,and postpone or even avoid the transplantation of liver and other organs.

关 键 词：垂体功能减退症 生长激素 肝硬化 肝肺综合征 

分 类 号：R584.2[医药卫生—内分泌]