Cancer cachexia:Focus on cachexia factors and inter-organ communication  

作　　者：Yongfei Wang Zikai Dong Ziyi An Weilin Jin 

机构地区：[1]The First Clinical Medical College of Lanzhou University,Lanzhou,Gansu 730000,China [2]Institute of Cancer Neuroscience,Medical Frontier Innovation Research Center,The First Hospital of Lanzhou University,The First Clinical Medical College of Lanzhou University,Lanzhou,Gansu 730000,China

出　　处：《Chinese Medical Journal》2024年第1期44-62,共19页中华医学杂志（英文版）

基　　金：supported by the High-Level Talent Introduction Funds from the First Hospital of Lanzhou University.

摘　　要：Cancer cachexia is a multi-organ syndrome and closely related to changes in signal communication between organs,which is mediated by cancer cachexia factors.Cancer cachexia factors,being the general name of inflammatory factors,circulating proteins,metabolites,and microRNA secreted by tumor or host cells,play a role in secretory or other organs and mediate complex signal communication between organs during cancer cachexia.Cancer cachexia factors are also a potential target for the diagnosis and treatment.The pathogenesis of cachexia is unclear and no clear effective treatment is available.Thus,the treatment of cancer cachexia from the perspective of the tumor ecosystem rather than from the perspective of a single molecule and a single organ is urgently needed.From the point of signal communication between organs mediated by cancer cachexia factors,finding a deeper understanding of the pathogenesis,diagnosis,and treatment of cancer cachexia is of great significance to improve the level of diagnosis and treatment.This review begins with cancer cachexia factors released during the interaction between tumor and host cells,and provides a comprehensive summary of the pathogenesis,diagnosis,and treatment for cancer cachexia,along with a particular sight on multi-organ signal communication mediated by cancer cachexia factors.This summary aims to deepen medical community’s understanding of cancer cachexia and may conduce to the discovery of new diagnostic and therapeutic targets for cancer cachexia.

关 键 词：Cancer cachexia Cancer cachexia factors Inter-organ communication Tumor ecosystem Tumor microenvironment 

分 类 号：R730.5[医药卫生—肿瘤]