Surgical site infections after elective craniotomy for brain tumor:a study on potential risk factors and related treatments  

作　　者：Yifan Lv Xiang Mao Yuxuan Deng Lanbing Yu Junsheng Chu Shuyu Hao Nan Ji 

机构地区：[1]Department of Neurosurgery,Beijing Tiantan Hospital,Capital Medical University,Beijing 100070,China [2]Department of Neurosurgery,The First Affiliated Hospital of Anhui Medical University,Hefei 230022,Anhui,China

出　　处：《Chinese Neurosurgical Journal》2023年第4期267-275,共9页中华神经外科杂志（英文）

摘　　要：Background Surgical site infection(SSI)is a common complication following craniotomy that increases morbidity,mortality,and medical expenses.The objectives of this study were to determine the relevant risk factors associated with SSI after elective craniotomy for brain tumor and analyse the treatments for SSI.Methods A retrospective nested case-control study was conducted using data from patients who underwent craniotomy for brain tumor resection at the Neurosurgical Oncology Department No.6 of Beijing Tiantan Hospital,Capital Medical University,between January 2019 and December 2021.Risk factors for SSI were determined using multivariate logistic regression analysis.We analyzed microbiological and related treatment data for different SSI types.Results Among 2061 patients who underwent craniotomy for brain tumor,31 had SSI(1.50%).In the multivariate logistic regression analysis,body mass index(BMI)and operative duration were identified as independent risk factors for SSI.The most common microorganism isolated from SSIs was Staphylococcus epidermidis(22.9%),and drug sensitivity results showed that gram-positive bacteria were sensitive to linezolid,vancomycin and tigecycline,whereas gram-negative bacteria were sensitive to meropenem,cefepime and ceftazidime.Six of the seven patients who underwent bone flap removal due to osteomyelitis were infected with gram-negative bacteria.Conclusions BMI and operative duration were identified as independent risk factors for SSI.Diabetes mellitus,previous ratio therapy,type of incision,recurrence tumor and other risk factors were not found to be associated with the occurrence of SSI in this study.

关 键 词：Brain tumor Elective craniotomy NEUROSURGERY Surgical site infection Risk factors Infection control 

分 类 号：R739.4[医药卫生—肿瘤]