Does the homologous booster with the inactivated coronavirus disease 2019 vaccine work for the omicron variant?Real-world evidence from Jilin,China  

作　　者：Jun Guo Lei Zha Kai Zeng Mingyu Shao Dan Chen Bing Wang Yun Zhou Gang Yang Xue Zhang Xia Zou Yan Zhang Yan Kang 

机构地区：[1]Department of Critical Care Medicine,West China Hospital,Sichuan University,Chengdu,Sichuan 610000,China [2]Intensive Care Unit,Conch Hospital of Anhui Medical University,Wuhu,Anhui 241000,China [3]Institute of Infection and Global Health,University of Liverpool,L697BE,Liverpool,UK [4]Critical Care Unit,The First Affiliated Hospital of Harbin Medical University,Harbin,Heilongjiang 150000,China [5]Hospital Administration Office,Jilin Central General Hospital,Jilin,Jilin 132000,China [6]Medical Administration Department,Jilin Central General Hospital,Jilin,Jilin 132000,China [7]Department of Cardiology,Jilin Central General Hospital,Jilin,Jilin 132000,China [8]Department of Pulmonary and Critical Care,Wuhu Hospital,East China Normal University,Wuhu,Anhui 241000,China [9]Department of Clinical Research Management,West China Hospital,Sichuan University,Chengdu,Sichuan 610000,China

出　　处：《Chinese Medical Journal》2023年第23期2892-2894,共3页中华医学杂志（英文版）

基　　金：Key Research and Development Project of the Science and Technology Department of Sichuan Province(No.2021YFS0003,Zygd18020);High-level Talents Fund of the Wuhu Municipal Government(No.2021-134)

摘　　要：To the Editor:The latest variant of concern,Omicron,has become the dominant global variant immediately after it was first reported in November 2021.[1]It contains>30 mutations in the spike protein,with 17 mutations in the receptor-binding domain,rendering it with increased transmissibility and capacity for immune evasion.[1,2]Moreover,the waning of protection has been observed over time since the coronavirus disease 2019(COVID-19)vaccination.[3]Therefore,a booster is highly recommended.A large-scale study in the UK assessing the effectiveness of the booster vaccination with either the BNT162b2 or mRNA-1273 indicated that the booster shot substantially increased protection against symptomatic infection in patients with the confirmed Omicron variant infection.[3]However,although the laboratory study has illustrated that the homologous booster with the inactivated COVID-19 vaccine could also yield potent neutralizing activity against the Omicron variant,[4]clinical evidence regarding the effectiveness of this vaccination program is limited.

关 键 词：VACCINATION HOMOLOGOUS RENDERING 

分 类 号：R186[医药卫生—流行病学]