Global and national burden of atherosclerosis from 1990 to 2019:trend analysis based on the Global Burden of Disease Study 2019  

作　　者：Weihua Chen Zeya Li Yu Zhao Yitian Chen Rongchong Huang 

机构地区：[1]Department of Cardiology,Beijing Friendship Hospital,Capital Medical University,Beijing 100053,China [2]Department of Cardiology,Longyan First Affiliated Hospital of Fujian Medical University,Longyan,Fujian 364000,China

出　　处：《Chinese Medical Journal》2023年第20期2442-2450,共9页中华医学杂志（英文版）

基　　金：supported by grants from the Summit Talent Plan,Beijing Hospital Management Center(No.DFL20190101,Beijing,China).

摘　　要：Background:Atherosclerosis-related diseases represent significant health issues among adults globally.Despite their widespread impact,comprehensive data concerning the global and national burden and trends of these diseases remain sparse.Our objective is to examine the trends in the burden of atherosclerosis among adults from 1990 to 2019 at both global and national levels.Methods:We reported the average annual percentage changes(AAPCs)in prevalence,incidence,mortality,and disabilityadjusted life years(DALYs)of atherosclerosis-related diseases(ischemic heart disease[IHD],ischemic stroke,and peripheral arterial disease[PAD])at the global and national levels among individuals based on a trend analysis of the Global Burden of Diseases Study(GBD)2019.We further analyzed these global trends as a function of age,gender,and the social development index.We also used joinpoint regression analysis to identify the year with the most substantial changes in global trends.Results:Globally,the AAPC of IHD incidence rose from 1990 to 2019(0.20;95%confidence interval[CI],0.12-0.28),with substantial surges in 1995,2001,2005,2010,and 2017.Conversely,AAPC of IHD mortality rates exhibited a different trend until a rise in 2014.The AAPC of incidence rates of ischemic stroke and PAD also escalated during the same period,with respective 0.43(95%CI,0.39-0.48)and 0.13(95%CI,0.06-0.21).For ischemic stroke,both incidence and mortality soared in 2014,while PAD incidence declined in 1994 and 1998,then sharply climbed in 2016.Nationally,the Northern Mariana Islands experienced the steepest increase in IHD and PAD incidence and mortality between 1990 and 2019.China saw a significant rise in ischemic stroke incidence,whereas the highest mortality rate increase occurred in Timor-Leste.By sociodemographic index(SDI)quintile,low-middle-,middle-,and high-middle-SDI countries all showed upward trends in IHD,ischemic stroke,and PAD incidence.Simultaneously,IHD and ischemic stroke mortality rates,as well as DALYs,dropped in the low-,high-middle-,and hi

关 键 词：ATHEROSCLEROSIS Disability-adjusted life years(DALYs) Global Disease Burden 2019 INCIDENCE MORTALITY 

分 类 号：R543.5[医药卫生—心血管疾病]