食管癌新辅助放化疗与新辅助化疗对比Meta分析  

Comparative meta-analysis of neoadjuvant chemoradiotherapy and neoadjuvant chemotherapy for esophageal cancer

作　　者：张云波[1] 李敬 于会明[3] 冯志峰 刘俊启[5] 郑丽萍[2] 张建光[1] Zhang Yunbo;Li Jing;Yu Huiming;Feng Zhifeng;Liu junqi;Zheng Liping;Zhang Jianguang(Department of Oncology,Zibo Wanjie Cancer Hospital,Zibo 255213,China;Department of Internal medicine,Zibo Wanjie Cancer Hospital,Zibo 255213,China;Department of Radiation Oncology,Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education),Peking University Cancer Hospital&Institute,Beijing 100142,China;Department of Oncology,Jishan Corntry People′s Hospital,Yuncheng 043299,China;Department of Radiotherapy,First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]淄博万杰肿瘤医院肿瘤科,淄博255213 [2]淄博万杰肿瘤医院内科,淄博255213 [3]北京大学肿瘤医院与研究所肿瘤发生与转化研究重点实验室(教育部)放射肿瘤科,北京100142 [4]山西省稷山县人民医院肿瘤科,运城043299 [5]郑州大学第一附属医院放疗科,郑州450052

出　　处：《中华转移性肿瘤杂志》2023年第2期128-133,共6页Chinese Journal of Metastatic Cancer

基　　金：淄博市医药卫生科研项目(20230903085)

摘　　要：目的系统评价新辅助放化疗和新辅助化疗在食管癌治疗中的作用。方法通过检索关于食管癌新辅助治疗的临床研究文献,收集符合要求的随机对照试验文献,运用Cochrace系统评价的方法,使用Review Manager5.3软件进行Meta分析。结果共纳入6篇文献,新辅助放化疗组460例,新辅助化疗组477例,病理类型为鳞癌和腺癌。在可切除率评价中纳入5篇文献,新辅助放化疗与新辅助化疗相比较,RR=1.0,95%CI为0.94~1.05,Z=0.16,P=0.87。在R0切除率评价中纳入4篇文献,新辅助放化疗与新辅助化疗相比较,RR=1.19,95%CI为1.09~1.29,Z=4.16,P<0.001。结论新辅助放化疗与新辅助化疗相比在可切除率方面无差异。R0切除率方面新辅助放化疗优于新辅助化疗。Objective To systematically evaluate the effects of neoadjuvant chemoradiotherapy and neoadjuvant chemotherapy in the treatment of esophageal cancer.Methods Through searching the clinical research literatures about the new adjuvant treatment of esophageal cancer,collecting the literatures of randomized controlled trials that meet the requirements,using the method of Cochrace system evaluation and Review Manager 5.3 software,the meta analysis was performed.Results A total of 6 literatures were included,including 460 cases in the neoadjuvant chemoradiotherapy group and 477 cases in the neoadjuvant chemotherapy group.The pathological types were squamous cell carcinoma and adenocarcinoma.Five articles were included in the resectable rate evaluation,comparing between the neoadjuvant chemoradiotherapy and neoadjuvant chemotherapy groups,RR was 1.0,95%CI was 0.94-1.05,Z=0.16,P=0.87.Four articles were included in the evaluation of R0 resection rate,comparing between the neoadjuvant chemoradiotherapy and neoadjuvant chemotherapy groups,RR was 1.19,95%CI was 1.09-1.29,Z=4.16,P<0.001.Conclusions There was no difference in resectability between neoadjuvant chemoradiotherapy and neoadjuvant chemotherapy.Neoadjuvant chemoradiotherapy was superior to neoadjuvant chemotherapy in terms of R0 resection rate.

关 键 词：食管癌 新辅助放化疗 新辅助化疗 可切除率 R0切除率 

分 类 号：R735.1[医药卫生—肿瘤]