多肽水凝胶在牙髓再血管化中的应用进展  

Research progress of the application of peptide hydrogel in the revascularization of pulp regeneration

作　　者：陈汝仪 邹慧儒[2,3] Chen Ruyi;Zou Huiru(Department of Stomatology,School of Stomatology,Tianjin Medical University,Tianjin 300070,China;Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction,Tianjin Stomatological Hospital,the Affiliated Stomatological Hospital of Nankai University,Tianjin 300041,China;School of Medicine,Nankai University,Tianjin 300071,China)

机构地区：[1]天津医科大学口腔医学院口腔医学系,天津300070 [2]天津市口腔医院暨南开大学附属口腔医院,天津市口腔功能重建重点实验室,天津300041 [3]南开大学医学院口腔医学系,天津300071

出　　处：《国际生物医学工程杂志》2023年第1期61-65,共5页International Journal of Biomedical Engineering

基　　金：天津市卫健委重点项目(ZD20016);天津市医学重点(发展)学科项目(TJYXZDXK-078D)

摘　　要：近年来,根管治疗后出现的牙髓活力丧失、牙齿脆性增加和牙体易折裂等问题逐渐引起重视,牙髓再生成为牙髓病和根尖周病治疗领域的研究热点。牙髓再生中的血管再生是重中之重。研究发现多肽水凝胶支架材料既能影响细胞行为,促进血管生成,还可以根据需要进行改性,应用灵活,受到了广泛关注。主要对离子互补性多肽、表面活性剂类多肽和化学基团修饰类多肽在牙髓再血管化中的应用进展进行综述,总结多肽水凝胶支架材料的特点,为其在牙髓再生中的进一步应用提供一定借鉴。In recent years,problems such as the devitalization of dental pulp and the increased brittleness and fragility of teeth after root canal treatment have attracted more and more attention.Therefore,pulp regeneration has become the focus of research in endodontics and periapical disease,in which vascularization is of paramount importance.It is found that peptide hydrogel scaffolds have been widely applied because of their properties of impacting cell behavior,promoting angiogenesis,and being adaptable.In this review paper,the research progress of the application of peptide hydrogel in the vascularization of pulp regeneration and the properties of various peptide hydrogels were summarized to provide a reference for the further application of peptide hydrogel in pulp regeneration.

关 键 词：多肽水凝胶 牙髓再生 血管化 支架材料 

分 类 号：R781.05[医药卫生—口腔医学]