Association of ERCC1 and XPF polymorphisms with pediatric glioma susceptibility  

作　　者：Yongping Chen Yuxiang Liao Xingyu Jia Huiran Lin Lei Miao Li Yuan Xiaokai Huang Jingying Zhou Jun Bian Zhenjian Zhuo 

机构地区：[1]Department of Pediatric Surgery,Guangzhou Institute of Pediatrics,Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease,Guangzhou Women and Children’s Medical Center,Guangzhou Medical University,Guangzhou,Guangdong 510623,China [2]Department of Neurosurgery,Xiangya Hospital,Central South University,Changsha,Hunan 410008,China [3]School of Medicine,Jinan University,Guangzhou,Guangdong 510632,China [4]Faculty of Medicine,Macao University of Science and Technology,Macao 999078,China [5]Department of Hematology,The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University,Wenzhou,Zhejiang 325027,China [6]Department of General Surgery,Xi’an Children’s Hospital,Xi’an Jiaotong University Affiliated Children’s Hospital,Xi’an,Shaanxi 710003,China [7]Laboratory Animal Center,School of Chemical Biology and Biotechnology,Peking University Shenzhen Graduate School,Shenzhen,Guangdong 518055,China

出　　处：《Chinese Medical Journal》2023年第6期746-748,共3页中华医学杂志（英文版）

基　　金：supported by grants from the National Natural Science Foundation of China(No.81802346);the China Postdoctoral Science Foundation(Nos.2020T130132,2020M682668)

摘　　要：To the Editor:Glioma is a highly invasive and lethal heterogeneous disease caused by glial or precursor cell mutation.It accounts for about 50%of tumors in children and 80%of malignant tumors.[1]The nucleotide excision repair(NER)pathway is a process that involves the sequential assembly of many proteins,including excision repair cross complementation group 1(ERCC1)and xeroderma pigmentosum complementation group F(XPF,also known as ERCC4).

关 键 词：ERCC1 XPF EXCISION 

分 类 号：R739.4[医药卫生—肿瘤]