复方福尔可定糖浆与复方可待因口服溶液用于肺癌相关性咳嗽疗效观察  

Efficacy of compound pholcodine syrup and compound codeine phosphate oral solution on lung cancer-related cough

作　　者：陈梦婷 肖小意 余慧青 王思雄 田玲 杨鸿 Chen Mengting;Xiao Xiaoyi;Yu Huiqing;Wang Sixiong;Tian Ling;Yang Hong(Department of Clinical Nutrition,Chongqing University Cancer Hospital,Chongqing 400030,China;Department of Geriatric Oncology,Chongqing University Cancer Hospital,Chongqing 400030,China)

机构地区：[1]重庆大学附属肿瘤医院营养科,重庆400030 [2]重庆大学附属肿瘤医院老年肿瘤科,重庆400030

出　　处：《中华医学杂志》2023年第13期975-980,共6页National Medical Journal of China

基　　金：重庆英才计划“包干制”项目(cstc2021ycjh-bgzxm0256);重庆市自然科学基金(cstc2019jcyj-msxmX0617、cstc2021jcyj-msxmX0400);重庆市沙坪坝区决策咨询与管理创新项目(Jcd202282)

摘　　要：目的观察复方福尔可定糖浆与复方可待因口服溶液用于肺癌相关性咳嗽的临床疗效。方法前瞻性选取2022年1至5月重庆大学附属肿瘤医院老年肿瘤科伴有肺癌相关性咳嗽的中晚期肺癌患者60例,按照随机数字表法将患者分为2组:(1)观察组:30例,男21例,女9例,年龄(62.3±10.4)岁;给予复方福尔可定糖浆治疗;(2)对照组:30例,男21例,女9例,年龄(62.0±8.1)岁;给予复方可待因口服溶液治疗;两种药物治疗剂量均为每次15 ml,每日3次,疗程均为5 d。比较两组患者治疗后第3天和第5天的镇咳有效率、咳嗽严重程度以及生活质量测评(中文版莱切斯特咳嗽问卷)评分的差异。结果60例患者均完成临床研究,两种药物均能有效控制肺癌相关性咳嗽。治疗后第3天,观察组与对照组的镇咳有效率分别为83.3%(25/30)、73.3%(22/30),差异无统计学意义(P=0.347)。治疗后第5天,观察组与对照组的镇咳有效率分别为90.0%(27/30)、86.6%(26/30),差异无统计学意义(P=0.687)。观察组治疗前中重度咳嗽患者占56.7%(17/30),对照组治疗前中重度咳嗽患者占67.7%(20/30),差异无统计学意义(P=0.414);治疗后第3天,两组患者咳嗽症状减轻,以轻度咳嗽为主,观察组轻度咳嗽患者占73.3%(22/30),对照组轻度咳嗽患者占56.7%(17/30),差异无统计学意义(P=0.331);治疗后第5天,观察组轻度咳嗽患者占86.7%(26/30),对照组轻度咳嗽患者占66.7%(20/30),差异无统计学意义(P=0.067)。两组患者治疗前、治疗后第3天、治疗后第5天中文版莱切斯特咳嗽问卷评分的生理评分、心理评分、社会评分及总分差异均无统计学意义(均P>0.05)。观察组口干及便秘发生率均为0,低于对照组的20.0%(6/30)、20.0%(6/30)(均P<0.05)。结论复方福尔可定糖浆与复方可待因口服溶液用于治疗肺癌相关性咳嗽均有效,镇咳有效率相近;复方福尔可定糖浆口干和便秘发生率更低,安全性可能更优。Objective To assess the clinical efficacy of compound pholcodine syrup and compound codeine phosphate oral solution on lung cancer-related cough.Methods A total of 60 patients diagnosed with middle-advanced stage lung cancer and had lung cancer-related cough in the Department of Geriatric Oncology of Chongqing University Cancer Hospital from January to May 2022 were prospectively enrolled.According to the random number table method,the patients were divided into two groups:observation group and control group.The observation group[n=30,with 21 males and 9 females,and aged(62.3±10.4)years]received compound pholcodine syrup treatment,while the control group[n=30,with 21 males and 9 females,and aged(62.0±8.1)years]received compound codeine phosphate oral solution treatment.The dosage of the two drugs was 15 ml each time,3 times a day,and the treatment course was 5 days.The antitussive effectiveness,cough severity and quality of life(Leicester Cough Questionnaire in Mandarin-Chinese scale)were observed and compared between the two groups 3 days and 5 days after the treatment.Results All 60 patients completed the study.Both regimens were effective in controlling lung cancer-related cough.After 3 days treatment,the antitussive effective rate of the observation group and the control group was 83.3%(25/30)and 73.3%(22/30),respectively,with no statistically significant difference(P=0.347).Likewise,after 5 days treatment,the antitussive effective rate of observation group and control group was 90.0%(27/30)and 86.6%(26/30),respectively,with no statistically significant difference(P=0.687).There was no statistically significant difference in the cough severity between observation group[moderate and severe cough:56.7%(17/30)]and control group[moderate and severe cough:67.7%(20/30)](P=0.414).After 3 days treatment,cough symptoms were relieved in both groups.Patients with mild cough accounted for 73.3%(22/30)in the observation group and 56.7%(17/30)in the control group,and the difference was not statistically significant(P=0.3

关 键 词：肺肿瘤 咳嗽 镇咳药 随机对照试验 

分 类 号：R734.2[医药卫生—肿瘤]