调控种植体骨整合的细胞信号通路研究进展  

Research progress in cell signaling pathways regulating implant osseointegration

作　　者：吕晓飞[1] 杨洁[1] Lv Xiaofei;Yang Jie(Department of Stomatology,the Second Hospital of Tianjin Medical University,Tianjin 300211,China)

机构地区：[1]天津医科大学第二医院口腔科,天津300211

出　　处：《国际生物医学工程杂志》2022年第5期437-441,447,共6页International Journal of Biomedical Engineering

基　　金：天津医科大学第二医院青年基金(2020ydey18)

摘　　要：目前种植修复已成为临床中治疗牙齿缺失的首选方案,种植义齿行使功能的基础是良好的种植体骨整合。骨整合是一个精细复杂的生物学过程,涉及分子水平到细胞水平的一系列变化,对其深入研究有利于新型种植体的研发,提高种植成功率。综述了种植体骨整合的生物学过程及整合素介导的信号通路、Wnt信号通路、转化生长因子-β(TGF-β)/骨形态发生蛋白(BMP)信号通路、缺氧诱导因子(HIFs)信号通路、Notch信号通路、Hippo信号通路等骨整合相关信号通路,为种植体性能的优化提供了一定的理论借鉴。Dental implant restoration has become the preferred clinical option for the treatment of tooth loss.The basis for the functioning of implant prostheses is good osseointegration of the implant.Osteointegration is a delicate and complex biological process that is not only a simple physical attachment but also initiates and regulates a series of important events such as cell survival,migration,recruitment,and osteogenic differentiation,involving a series of physicochemical changes from the molecular to the cellular level.In-depth studies on osseointegration can facilitate the development of new implants,improve the success rate of implantation in complex clinical conditions,and have important implications for the prevention and treatment of peri-implant diseases.In this review,the research on the regulation of cell signal pathways of implant osseointegration was reviewed,including the biological process of implant osseointegration,integrin-mediated signal pathways,Wnt signal pathways,transforming growth factor-β(TGF-β)/bone morphogenetic protein(BMP)signal pathways,hypoxia-inducible factors(HIFs)signal pathways,Notch signal pathways,Hippo signal pathways,and other signal pathways related to bone integration that are expected to provide some theoretical reference for the optimization of implant performance.

关 键 词：种植体 骨整合 信号通路 

分 类 号：R783.6[医药卫生—口腔医学]