中医二联疗法预防恶性肿瘤化疗相关性贫血效果观察  

Efficacy observation on prevention of chemotherapy-related anemia by combined therapy of traditional Chinese medicine in malignant tumors

作　　者：张昌文 毛毛[1] 许冬鑫 焦宁[1] 徐雨 陈丽芳 张金兰[1] Zhang Changwen;Mao Mao;Xu Dongxin;Jiao Ning;Xu Yu;Chen Lifang;Zhang Jinlan(Department of Oncology and Hepatology,Zibo Hospital of Traditional Chinese Medicine,Zibo 255300,China;Shandong University of Traditional Chinese Medicine)

机构地区：[1]淄博市中医医院肿瘤肝病科,淄博255300 [2]山东中医药大学

出　　处：《肿瘤研究与临床》2023年第2期133-136,共4页Cancer Research and Clinic

基　　金：山东省中医药科技项目面上项目(2020M113)

摘　　要：目的探讨中医二联疗法预防恶性肿瘤化疗相关性贫血的有效性。方法选取2019年1月至2021年1月在淄博市中医医院确诊的恶性肿瘤患者79例,按照随机数字表法分为试验组(40例)与对照组(39例)。对照组接受化疗,试验组接受化疗联合中医二联疗法(五红汤联合艾灸)。记录2组化疗前及化疗后第7、14和21天时血红蛋白(Hb)水平、Karnofsky评分及不良反应。结果化疗后第21天试验组Hb水平高于对照组[(117±28)g/L比(100±31)g/L],差异有统计学意义(t=-3.08,P=0.030)。试验组总有效率高于对照组[85%(34/40)比66.7%(26/39)],但差异无统计学意义(χ^(2)=4.96,P=0.084)。试验组治疗前、治疗后第21天Karnofsky评分分别为(77±9)分、(77±12)分,差异无统计学意义(t=-0.50,P=0.623);对照组分别为(78±10)分、(67±9)分,差异有统计学意义(t=8.32,P<0.001);治疗前两组Karnofsky评分差异无统计学意义(t=1.85,P=0.068),治疗后第21天试验组高于对照组(t=4.88,P<0.001)。两组恶心、呕吐发生率差异无统计学意义(P>0.05),两组均未出现化疗相关肝、肾及心脏不良反应。结论中医二联疗法可有效预防恶性肿瘤化疗相关性贫血,提高患者生命质量。Objective To explore the effect of combined therapy of traditional Chinese medicine on prevention of chemotherapy-related anemia in malignant tumors.Methods Seventy-nine patients with malignant tumors diagnosed in Zibo Hospital of Traditional Chinese Medicine from January 2019 to January 2021 were selected,and the patients were divided into experimental group(40 cases)and control group(39 cases)according to the random number table method.The control group received chemotherapy and the experimental group received chemotherapy and combined therapy of traditional Chinese medicine(Wuhong Tang combined with moxibustion).The hemoglobin(Hb)level,Karnofsky score and adverse effects were recorded before and on days 7,14 and 21 after chemotherapy in the two groups.Results The Hb level in the experimental group was higher than that in the control group[(117±28)g/L vs.(100±31)g/L]on day 21 after chemotherapy,and the difference was statistically significant(t=-3.08,P=0.030).The total effective rate of the experimental group was higher than that of the control group[85%(34/40)vs.66.7%(26/39)],but the difference was not statistically significant(χ^(2)=4.96,P=0.084).Karnofsky scores were(77±9)points and(77±12)points before and on day 21 after treatment in the experimental group,with no statistical difference(t=-0.50,P=0.623);Karnofsky scores were(78±10)points and(67±9)points in the control group,with statistical difference(t=8.32,P<0.001).There was no statistical difference in Karnofsky score before treatment between the two groups(t=1.85,P=0.068),but the experimental group was higher than the control group on day 21 after treatment(t=4.88,P<0.001).The difference in the incidence of nausea and vomiting between the two groups was not statistically significant(P>0.05),and no chemotherapy-related hepatic,renal or cardiac adverse reactions were observed in either group.Conclusions Combined therapy of traditional Chinese medicine could effectively prevent chemotherapy-related anemia and improve the quality of life of patients.

关 键 词：肿瘤 化疗相关性贫血 中医二联疗法 五红汤 艾灸 

分 类 号：R730.53[医药卫生—肿瘤] R556[医药卫生—临床医学]