免疫检查点抑制剂联合低剂量照射治疗非小细胞肺癌研究进展  

Progress of immune checkpoint inhibitors combined with low-dose irradiation in treatment of non-small cell lung cancer

作　　者：彭杨 马代远[1] Peng Yang;Ma Daiyuan(Department of Oncology,Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,China)

机构地区：[1]川北医学院附属医院肿瘤科,南充637000

出　　处：《肿瘤研究与临床》2023年第2期147-150,共4页Cancer Research and Clinic

摘　　要：免疫检查点抑制剂(ICI)的应用改写了目前非小细胞肺癌的治疗格局,但单药ICI存在获益人群小、减瘤效应展现较慢等缺点,故各种免疫联合其他治疗手段的研究逐渐成为临床热点方向。低剂量照射具有激活机体免疫而产生的显著抗肿瘤协同作用,其体现出了辅助免疫治疗的潜能,使传统放疗从局部根治性治疗手段向免疫佐剂转变。文章就ICI联合低剂量照射治疗非小细胞肺癌的研究进展进行综述。The application of immune checkpoint inhibitors(ICI)has rewritten the current treatment pattern of non-small cell lung cancer.However,single-agent ICI has disadvantages such as small benefit population and slow tumor cytoreduction effect.Therefore,various immunizations combined with other treatment methods are becoming clinical hotspots.Low-dose irradiation shows a significant anti-tumor synergistic effect through activating the body's immune system,and its potential for adjuvant immunotherapy has transformed traditional radiotherapy from local radical treatment to immune adjuvant.This article reviews the current research progress of ICI combined with low-dose irradiation in the treatment of non-small cell lung cancer.

关 键 词：癌 非小细胞肺 免疫检查点抑制剂 低剂量照射 放射治疗 

分 类 号：R734.2[医药卫生—肿瘤]