儿童颅外恶性生殖细胞肿瘤诊治的国际研究进展  

Recent advances of diagnosing and treating malignant extracranial germ cell tumors in children

作　　者：茅君卿[1] 李林洁[1] 李民驹[1] 蔡嘉斌[1] 贺敏[1] 熊洁妮 管忠海 王金湖[1] Mao Junqing;Li Linjie;Li Minju;Cai Jiabin;He Min;Xiong Jieni;Guan Zhonghai;Wang Jinhu(Affiliated Children's Hospital,Zhejiang University School of Medicine,Hangzhou 310052,China)

机构地区：[1]浙江大学医学院附属儿童医院肿瘤外科,杭州310052

出　　处：《临床小儿外科杂志》2022年第12期1134-1140,共7页Journal of Clinical Pediatric Surgery

基　　金：浙江省自然科学基金青年项目(LQ20H160027)

摘　　要：生殖细胞肿瘤是来源于原始生殖细胞的一组异质性疾病,发病部位可为性腺,也可为性腺外。根据组织学特征分为畸胎瘤、恶性生殖细胞肿瘤、混合性生殖细胞肿瘤。目前国际上研究儿童生殖细胞肿瘤的主要协作组织有由美国、加拿大和澳大利亚组成的儿童肿瘤协作组(Children's Oncology Group,COG)和英国的儿童癌症与白血病研究组(Children's Cancer and Leukaemia Group,CCLG)。本文针对儿童颅外恶性生殖细胞肿瘤的临床分期,危险度分组,化疗方案及难治、复发性患儿治疗的国际研究进展进行综述。Germ cell neoplasms are a group of heterogeneous diseases derived from primitive germ cells.Histological types are classified as teratoma,malignant germ cell tumor and mixed germ cell tumor.The major international collaborations for the study of reproductive cell tumors in children are Children's Oncology Group(COG)in the United States,Canada and Australia and Children's Cancer and Leukaemia Group(CCLG)in the United Kingdom.This review summarized the latest international research advances in clinical stages,risk groups,chemotherapeutic regimens and managements of refractory and recurrent children with extracranial malignant germ cell tumors.

关 键 词：生殖细胞瘤 恶性肿瘤 性腺 解剖学 组织学 诊断 治疗 儿童 

分 类 号：R73[医药卫生—肿瘤]