肿瘤淋巴结转移:肿瘤细胞与免疫系统的博弈  

Lymph node metastasis of tumor:the battle between tumor cells and immune system

作　　者：章梓郁 杜楠楠 李源茂 王玉玲 李敏[1,2,3,4,5,6,7] Zhang Ziyu;Du Nannan;Li Yuanmao;Wang Yuling;Li Min(Department of Respiratory Medicine,National Key Clinical Specialty,Branch of National Clinical Research Center for Respiratory Disease,Xiangya Hospital,Central South University,Changsha 410005,China;Xiangya Lung Cancer Center,Xiangya Hospital,Central South University,Changsha 410005,China;Xiangya Cancer Center,Xiangya Hospital,Central South University,Changsha 410005,China;Center of Respiratory Medicine,Xiangya Hospital,Central South University,Changsha 410005,China;Clinical Research Center for Respiratory Diseases in Hunan Province,Changsha 410005,China;Hunan Engineering Research Center for Intelligent Diagnosis and Treatment of Respiratory Disease,Changsha 410005,China;National Clinical Research Center for Geriatric Disorders,Changsha 410005,China)

机构地区：[1]中南大学湘雅医院呼吸内科,国家呼吸疾病临床医学研究中心分中心,长沙410005 [2]中南大学湘雅医院肺癌诊疗中心,长沙410005 [3]中南大学湘雅医院肿瘤医学中心,长沙410005 [4]中南大学湘雅医院呼吸中心,长沙410005 [5]湖南省呼吸疾病临床医学研究中心,长沙410005 [6]呼吸疾病智能诊疗技术湖南省工程研究中心,长沙410005 [7]国家老年疾病临床医学研究中心,长沙410005

出　　处：《中华转移性肿瘤杂志》2022年第4期357-361,共5页Chinese Journal of Metastatic Cancer

基　　金：国家重大疾病(肺癌)多学科合作诊疗能力建设项目(Lung Cancer,z027002);国家自然科学基金(81903020);湖南省科技重大专项(2019SK2251)

摘　　要：淋巴结转移是肿瘤转移最早发生、最常见的事件,与患者预后密切相关。在免疫治疗时代,肿瘤引流淋巴结(TDLN)作为抗肿瘤免疫关键器官,其在肿瘤发展过程中所起的作用受到越来越多的关注。TDLN发生肿瘤转移后通过多方面机制创造出特殊的微环境,此微环境不仅通过改变肿瘤细胞的代谢等特性进而影响其增殖和迁移侵袭能力,并且作用于多种免疫细胞导致免疫耐受和免疫抑制,而后者正好对应免疫治疗的重要内容。本篇综述旨在讨论TDLN在肿瘤细胞转移之后对肿瘤细胞和免疫系统的调控作用,探讨淋巴结转移在免疫治疗时代的临床新定义和新价值,以期为免疫治疗改良提供新的方向。Tumor metastasis is one of the important reasons for poor prognosis of tumor patients,in which lymph node metastasis is the earliest and most frequent event.With the development of immunotherapy,tumor draining lymph nodes(TDLN),especially tumor-metastatic draining lymph nodes,as the key immune organ of anti-tumor immunity,has been paid more attention in the process of tumor development.After tumor metastasis,TDLN creates a special tumor immune microenvironment through various mechanisms,and this microenvironment may not only change the metabolism and other characteristics of tumor cells and then affect their ability of proliferation,migration and invasion,but also influence various kinds of immune cells in lymph nodes,leading to the emergence of immune tolerance and immunosuppression,which exactly responds to immune checkpoint blockade therapy.In this review,we discussed the regulatory effect of TDLN on tumor cells and immune system after tumor cell metastasis,and the new clinical definition and value of lymph node metastasis in the era of immunotherapy,which provides a new direction to refine immune therapy strategies.

关 键 词：肿瘤引流淋巴结 淋巴结转移 肿瘤/免疫疗法 调控作用 

分 类 号：R73[医药卫生—肿瘤]