儿童重症肌无力诊疗进展  

Progress in diagnosis and treatment of myasthenia gravis in children

作　　者：黄茜 杨丽芬[1] 陈柏渝 尹飞[1] Huang Xi;Yang Lifen;Chen Baiyu;Yin Fei(Department of Pediatric Neurology,Xiangya Hospital,Central South University,Changsha 410008,China)

机构地区：[1]中南大学湘雅医院儿童神经专科,长沙410008

出　　处：《中国医师杂志》2022年第10期1454-1459,共6页Journal of Chinese Physician

基　　金：湖南省重点领域研发计划(2019SK2081)

摘　　要：重症肌无力(MG)主要是由细胞及体液免疫依赖、补体及细胞因子参与、多种抗体介导的引起神经肌肉接头(NMJ)传递障碍的自身免疫性疾病。MG是儿童神经专科常见的自身免疫性疾病之一,在诊断及治疗上与成人MG有较大的区别,而目前临床仍缺乏针对儿童MG精准、高效的诊疗方案。近年来,随着MG发病机制研究的深入,免疫病理环节中免疫网络紊乱及导致NMJ传递障碍的致病抗体的靶向诊疗成为当前主要研究方向。本文对儿童MG辅助检查、治疗方案选择的进展作一综述。Myasthenia gravis(MG)is an autoimmune disease with neuromuscular junction(NMJ)transmission disorder mediated by various antibodies,dependent on cellular immunity,and involved in complement and cytokines.MG is one of the common diseases in pediatric neurology,which is different from adult MG in diagnosis and treatment.However,there is still a lack of accurate and efficient diagnosis and treatment plan for pediatric MG.In recent years,with the development of pathogenesis,targeted diagnosis and treatment of NMJ transmission disorders caused by immune network disorders in immunopathology and pathogenic antibodies is the current main research direction.This article reviews the progress of auxiliary examination and treatment of MG in children.

关 键 词：重症肌无力 儿童 

分 类 号：R74[医药卫生—神经病学与精神病学]