食管癌干细胞放化疗抗拒的机制研究进展  

Research progress on the mechanism of chemoradiotherapy resistance of esophageal cancer stem cells

作　　者：于兰[1] 张红梅[1] 陈存海 张小涛 Yu Lan;Zhang Hongmei;Chen Cunhai;Zhang Xiaotao(Department of Radiotherapy,Affiliated Qingdao Central Hospital,Qingdao University,Qingdao 266042,China;Department of Radiation Physics,Affiliated Qingdao Central Hospital,Qingdao University,Qingdao 266042,China)

机构地区：[1]青岛大学附属青岛市中心医院放疗科,青岛266042 [2]青岛大学附属青岛市中心医院放射物理科,青岛266042

出　　处：《中华转移性肿瘤杂志》2022年第3期270-274,共5页Chinese Journal of Metastatic Cancer

摘　　要：晚期食管癌以放化疗综合治疗为主,而食管癌干细胞(ECSC)的存在是肿瘤对化疗和放疗抗拒以及治疗后进展失败的重要原因。这部分细胞的高致瘤性、高侵袭性和多重耐药等特性,最终导致治疗失败。研究证实,ECSC的表面标志物可作为预测食管癌患者放化疗疗效和预后的指标。肿瘤相关的多信号通路途径以及肿瘤微环境也参与肿瘤干细胞的发生、侵袭、转移以及对放化疗抗拒等环节。因此,深入研究ECSC放化疗抗拒的机制将有助于实现食管癌治疗新策略。Radiotherapy and chemotherapy are the main treatment for advanced esophageal cancer,and esophageal cancer stem cells(ECSC)are mainly responsible for chemoradiotherapy resistance and treatment failure.These cancer stem cells(CSC)harbor unique properties including high tumorigenicity,proliferation,migration,and resistance to conventional therapy,leading to treatment failure.Studies have confirmed that the surface markers of ECSC can predict the efficacy and prognosis of radiotherapy and chemotherapy in patients with esophageal cancer.In addition,multiple tumor signal pathways and tumor microenvironment are also involved in the occurrence,invasion,metastasis,and chemoradiotherapy resistance of CSC.Therefore,an in-depth study of the mechanism of chemoradiotherapy resistance in ECSC will help to achieve new strategies for the treatment of esophageal cancer.

关 键 词：食管肿瘤 肿瘤干细胞 放疗抵抗 化疗抵抗 机制 

分 类 号：R73[医药卫生—肿瘤]