急性脑梗死患者血浆GMP-140浓度与血小板聚集功能相关性研究  

The relativive studies between the concentration of GMP-140 in plasma and platelet aggregation in patients with acute cerebral infarction

作　　者：郑悦[1] 聂志余[1] 张仲慧[1] 王永才[2] 

机构地区：[1]大连医科大学第二临床学院神经内科,辽宁大连116027 [2]大连医科大学第二临床学院检验科,辽宁大连116027

出　　处：《大连医科大学学报》2001年第2期85-86,共2页Journal of Dalian Medical University

基　　金：辽宁省教委基金资助课题! (970 72 2 10 72 )

摘　　要：目的 :探讨急性脑梗死血浆GMP - 140浓度与血小板聚集功能的相关性及临床意义。方法 :对 4 5例急性脑梗死患者进行研究 ,与 2 0例健康人作对照 ,在发病 3天内 (急性期 )及 2周时 (恢复期 )抽取肘静脉血 ,采用酶联免疫吸附双抗体夹心法测定血浆GMP - 140浓度、血小板聚集率(PAgT)采用TYXN - 96I多功能智能血液仪测定。结果 :血浆GMP - 140浓度与PAgT呈显著正相关(r =0 .538,P <0 0 1)。脑梗死急性期血浆GMP - 140浓度、PAgT显著高于恢复期和对照组 (P<0 0 0 1) ,恢复期血浆 (GMP - 140浓度高于对照组 (P <0 0 1) ,而PAgT与对照组无显差异。结论 :急性脑梗死血浆GMP - 140浓度与PAgT呈正相关 ,恢复期血奖GMP - 140浓度能更准确地反映血小板活化程度 。Objective:To study the relativity between the concentration of GMP-140 in plasma and platelet aggregation in patients with acute cerebral infarction and the clinical significance.Methods 45patients(male 22,female 23)with acute cerebral infarction and 20 normal control cases(male 12,female 18)with age and sex matched participated in this study.The venous blood were collected within 3 days and in 2 weeks after stroke.The concentration of GMP-140 in plasma measured by two-antibody-sandwich method ELISA and pl...

关 键 词：急性脑梗死 GMP-140 血小板聚集率 

分 类 号：R743.32[医药卫生—神经病学与精神病学]