Comparative Analysis of Therapeutic Effects of Esomeprazole and Omeprazole in Patients with Gastric Ulcer  

作　　者：WANGXiumei 

机构地区：[1]Zhuyouguan Center Health Center, Longkou City, Yantai Shandong 265705, China

出　　处：《外文科技期刊数据库(文摘版)医药卫生》2022年第7期074-078,共5页

摘　　要：Objective: to compare and analyze the pharmacological effects, therapeutic effects and drug safety of different proton pump inhibitors (PPI) in the treatment of gastric ulcer patients. Methods: according to the random grouping method, 120 patients with Hp positive gastric ulcer were divided into ASM group and a group, with 60 cases in each group. The two groups carried out the same treatment plan, that is, two kinds of antibiotics + gastric mucosal protectant +PPI. In the treatment of PPI drugs, esomeprazole and omeprazole were used respectively. Establish observation indicators: clinical efficacy, anti HP effect, ulcer surface healing effect, serum gastric mucosal injury factor, gastric function indicators serum gastrin (gas), motilin (MTL), active intestinal peptide (VIP)], adverse reactions. Results: after treatment, the score of main symptoms of gastric ulcer in ASM group was lower than that in group A (P < 0.05). In terms of clinical treatment efficiency, the ASM group was 93.33%, higher than 80% in group A (P < 0.05). The eradication rate of HP in ASM group was 85% (51/60), which was higher than 71.67% (43/60) in group A. The healing rate of ulcer surface in ASM group was 90%, which was higher than 76.67% in group A (P < 0.05). After treatment, serum PGE2, EGF and SOD in ASM group were higher than those in group A (P < 0.05), serum gas and VIP in ASM group were lower than those in group A (P < 0.05), and MTL was higher than that in group A (P < 0.05). Patients in ASM group and group A had no obvious adverse reaction symptoms during treatment, and could tolerate treatment. Conclusion: compared with omeprazole, esomeprazole has better curative effect on Hp positive gastric ulcer. Whether in terms of anti HP infection or ulcer healing effect, esomeprazole has higher medicinal value, better effect on improving gastric function of patients, and good safety.

关 键 词：gastric ulcer OMEPRAZOLE OMEPRAZOLE Hp eradication ulcer healing gastric function 

分 类 号：R453[医药卫生—治疗学]