缺血性脑卒中患者脑出血风险预测因素  

Forecast factors of intracerebral hemorrhages risk in ischemic strokes' patients

作　　者：范蓉[1] 尹琳[1] 王乃昌[1] 包礼平[1] 

机构地区：[1]大连医科大学附属第二医院神经内科,辽宁大连116023

出　　处：《华北煤炭医学院学报》2007年第2期149-150,共2页Journal of North China Coal Medical College

摘　　要：①目的探讨缺血性卒中患者应用抗血小板药物或抗凝药物等抗栓治疗导致脑出血的主要危险因素。②方法患者分3组,Ⅰ组为缺血性卒中后再发脑出血的患者,Ⅱ组为同时间住院的脑出血患者,Ⅲ组为缺血性卒中后长期口服抗凝或抗血小板治疗而无脑出血发生的患者,分别对其年龄、性别、高血压、糖尿病、过去脑梗死时间、抗凝及抗血小板药物、服用时间及止血参数等资料进行综合分析。③结果Ⅰ组和Ⅱ组比较,有卒中史者多于Ⅱ组;Ⅰ组和Ⅲ组比较,其年龄大,卒中史次数多、血压高,服药时间短,血小板数目减少明显,PT,TT时间延长。④结论缺血性卒中的患者应用抗血小板药物或抗凝药物等抗栓治疗是导致脑出血的主要危险因素,因此避免抗凝及抗血小板药物应用过量,有助于减少脑出血的发生。Object To discuss the main risk factors of intracerebral hemorrhages(ICH) caused by antithrombotic therapy,such as antiplatelet drugs and anticoagulants,in ischemic strokes'patients.Methods All patients were assigned to three groups.Group 1 was the ICH patients after ischemic stroke,Group 2 was the spontaneous ICH patients in hospitals during the same time and Group 3 was the patients without ICH treated by the oral anticoagulants and antiplatet drugs after ischemic strokes.Their ages,gender,blood pressure,diabetes,the time of previous cerebral ischemia,anticoagulants and antiplatelet drugs,the time of taking medicines and parameters of hemostasis were analyzed.Results Compared Group 1 with Group 2,Group 1 had more patients with ischemic disease history.While compared Group 1 with Group 3,the age was older,the times of ischemic disease history was more,blood pressure was high,the time of taking drugs was shorter,the number of platelet was decreased and the time of PT and TT was prolonged in the patients of Group 1.Conclusion The main risk factors of intracerebral hemorrhages(ICH) are the antithrombotic therapy in ischemic strokes'patients.The anticoagulants and antiplatelet drugs aren't used excessively,it will reduce the occurrence of ICH.

关 键 词：缺血性脑卒中 抗血小板药物 抗凝药物 脑出血 

分 类 号：R743[医药卫生—神经病学与精神病学]