槐胺碱的心血管作用  

CARDIOVASCULAR EFFECTS OF SOPHORAMINE

作　　者：崔小卫[1] 冯高闳[1] 

机构地区：[1]江西医学院药理教研室,南昌330006

出　　处：《中国药理学通报》1990年第5期321-324,共4页Chinese Pharmacological Bulletin

摘　　要：槐胺碱(Sa)对麻醉猫、兔和大鼠均有明显的降压作用,降压机理与交感神经节阻断作用和直接扩张外周血管有关。离体心脏实验表明,Sa有负性频率,增加冠脉流量和一定的正性肌力作用。Sa能推迟乌头碱诱发的大鼠心律失常发生时间,缩短心律失常的持续时间,并能降低氯仿诱发的小鼠室颤发生率。其对实验性血栓形成和ADP诱导的血小板聚集作用无影响。Sophoramine ( Sa ) is an alkaloid from sophora alopecuroides. Linn., in anesthetize animals ( cat, rat and rabbit), intravenous adminstra-tion of Sa reduced rapidly and markly the arterial blood pressure. The mechanism of hypotension effect of Sa is mainly attributable to its sympathetic ganglionic blocking and direct vasodilatation. Experiment on the isolated hearts of guinea pig revealed that Sa produced negative chronotropic and positive inotropic action, and increased coronary flow simultaneously. In...

关 键 词：槐胺碱 降压作用 交感神经节 正性肌力作用 血管扩张 心律失常 

分 类 号：R96[医药卫生—药理学]