石蒜碱内铵盐对小鼠艾氏腹水癌细胞周期及核分裂的影响  

INFLUENCE OF LYCOBETAINE ON THE CELL CYCLE & MITOSIS IN MOUSE EHRLICH CARCINOMA CELLS

作　　者：周佩琴 胥彬[1] 薛绍白[2] 宋平根[2] 

机构地区：[1]中国科学院上海药物研究所 [2]北京师范大学

出　　处：《中国药理学通报》1989年第2期89-91,共3页Chinese Pharmacological Bulletin

摘　　要：石蒜碱内铵盐是一种有效的抗癌物质,本工作以荧光激活细胞分类器方法证明,它在治疗剂量40mg/kg时能使G_1期细胞百分比下降,G_2+M期细胞明显上升,对G_2期细胞向G_1期的过渡有阻滞作用。在给药后8～72h使癌细胞有丝分裂指数明显下降。至第6d趋向恢复。此药对早期和中期细胞分裂象的抑制作用较强,尤其在用药后8h为最显著,对晚期、末期的作用不明显。Lycobetaine ( AT-1840 ) is an effective antitumor substance. In the present work it was demonstrated that in a dose of 40 pig/kg AT-1840 could decrease the percentage of G, cells, meanwhile it increased G2 + M cells remarkably by means of flow fluocytometry method, AT-1840 could also inhibit the progression of cells from G2 to G1 phase. 8 to 72 h after, the injection the mitotic index was decreased significantly and recovered gradually in 6 d. It could inhibit the prophase and metaphase greatly, but had no ...

关 键 词：石蒜碱内铵盐 有丝分裂 细胞周期 

分 类 号：R96[医药卫生—药理学]