周围型非小细胞肺癌的CT征象与ABH(O)血型抗原表达的相关性研究  

Correlative Study of CT Manifestations and Expression of Blood-group Antigen ABH in Peripheral Non-small-cell Lung Cancer

作　　者：赵欣[1] 曾纪珍[2] 周晓琳 周建华[4] 夏宇[2] 陈友良[2] 朱智明[2] 

机构地区：[1]广东顺德市容奇医院放射科,528303 [2]中南大学附属湘雅医院放射科,410007 [3]湖南省长沙市一医院CT室,410005 [4]中南大学医学院病理学教研室,410007

出　　处：《临床放射学杂志》2001年第8期591-596,共6页Journal of Clinical Radiology

摘　　要：目的　探讨周围型非小细胞肺癌 (NSCLC)的CT征象与ABH(O)血型抗原 (BGA)表达的相关性。材料与方法　对 72例经手术病理证实的周围型NSCLC患者术前进行CT扫描 ,并用SP法对肿瘤标本BGA进行免疫组化染色。结果　 ( 1)肿瘤BGA表达阴性率随着病理分级的增加而增高 (P <0 .0 1) ,且在有淋巴结转移或肺外浸润组中明显升高 (P <0 .0 0 5 )。 ( 2 )CT征象中 ,肿块最大径 >3cm组其肿瘤BGA表达阴性率比≤ 3cm组高 (P <0 .0 0 5 ) ;有纵隔淋巴结增大组其肿瘤BGA表达阴性率高于无纵隔淋巴结增大组 (P <0 .0 0 5 ) ;胸膜受累胸膜外脂肪线消失组其BGA表达阴性率高于胸膜外脂肪线存在组 (P <0 .0 0 5 ) ;具有含气支气管征或空泡征的肺腺癌BGA表达阴性率低于无此征象的肿瘤 (P <0 .0 5 ) ,肿瘤BGA表达阴性组的强化曲线与阳性组间有差别 ,前者CT值在达到了强化峰值后有下降更快的趋势 (P≤ 0 .0 5 )。结论　CT显示肺癌瘤体 >3cm ,含气支气管征、空泡征、胸膜受累胸膜外脂肪线消失。Objective To study the correlation between CT appearance and the expression of blood group antigen ABH (BGA) in peripheral non small cell lung cancer (NSCLC).Materials and Methods CT scan was performed in 72 cases with surgically and pathologically proved NSCLC before operation. The presence of BGA was assessed immunohistochemically using paraffin embedded tumor samples with streptavidin peroxidase conjugated method.Results (1) The negative rate of BGA was significantly higher in tumors with a diam...

关 键 词：肺肿瘤 肿瘤 ABH(O)血型抗原 预后 体层摄影术 X线计算机 

分 类 号：R734.2[医药卫生—肿瘤]