A型肉毒毒素在甲状腺相关眼病限制性斜视治疗中的应用  

The application of botulinum toxin A in the treatment of restrictive strabismus in thyroid associated ophthalmopathy

作　　者：吴晓[1] 林楠[1] 艾立坤[1] 王京辉[1] 闫丽娟[2] 

机构地区：[1]首都医科大学北京同仁眼科中,100730 [2]首都医科大学北京同仁眼科中心,100730

出　　处：《中华眼科杂志》2006年第12期1063-1067,共5页Chinese Journal of Ophthalmology

摘　　要：目的探讨A型肉毒毒素(BTXA)治疗甲状腺相关眼病(TAO)限制性斜视的疗效及作用特点。方法回顾性分析BTXA眼外肌注射治疗TAO限制性斜视的临床资料,在肌电图的引导下,对33例TAO限制性斜视患者的眼外肌肌腹注射BTXA,注射前后记录眼位、眼球运动、复视等情况。结果本组患者垂直斜视25例,水平斜视3例,水平斜视合并垂直斜视5例。水平斜视度平均35·00△±20·53△(20△~80△,M=27·5△),垂直斜视度29·33△±17·27△(10△~100△,M=27·5△)。随诊时间5·00~67·73个月,平均(17·04±12·77)个月。注射眼外肌61条,其中下直肌31条,内直肌16条,上直肌10条,外直肌4条。每条眼外肌平均注射次数(6·48±2·12)次,(4~11次,M=6次)。注射间隔时间0·50~26·00个月,平均(2·96±0·70)个月。注射后斜视度减小,治愈15例,有效12例,治疗无效6例。单次注射用药剂量平均(8·16±1·43)U。结论BTXA治疗TAO引起的限制性斜视效果良好。注射时机以TAO早期为佳。每次注射BTXA剂量大于麻痹性斜视和共同性斜视的用量,矫正的斜视度较低,注射...Objective To observe the clinical effects of botulinum toxin A in the treatment of restrictive strabismus in thyroid associated ophthalmopathy (TAO). Methods Clinical data in 33 patients with restrictive strabismus in TAO treated with botulinum toxin A were analyzed retrospectively. Botulinum toxin A was injected into extraocular muscles guided by electromyography. Clinical data included the eye position, the eye movement and diplopia. Results There were 25 cases of vertical strabismus, 3 horizontal strabis...

关 键 词：格雷夫斯病 斜视 肉毒杆菌毒素 A型 注射 病灶内 

分 类 号：R777.41[医药卫生—眼科]