SD大鼠无菌性腹膜炎的形态学改变  

Morphological Study on Aseptic Peritonitis in SD Rat

作　　者：白文霞 潘玉英[1] 苏宁[2] 

机构地区：[1]江苏省药物安全性评价中心,南京210009 [2]东南大学病理教研室

出　　处：《四川动物》2006年第3期641-643,共3页Sichuan Journal of Zoology

摘　　要：目的-了解以40%酒精为溶媒经腹腔连续注射SD大鼠后所发生的无菌性腹膜炎的组织病理学改变。方法-SD大鼠脏器分离后固定于11%福尔马林内,常规脱水、透明、石蜡包埋,制片,HE染色,光学显微镜观察。结果-对照组大鼠未发生腹膜炎,溶媒组和给药组大鼠可见较严重的腹膜炎,其主要病理改变发生在肝、脾、胰、胃肠道、子宫、膀胱等脏器的脏层腹膜。肝、脾、胰被膜增厚、机化。胃肠道、子宫浆膜增厚、机化。膀胱外膜增厚、机化。上述损害停药4周也未见恢复。结论-高浓度酒精为主要成分的溶媒经腹腔连续给药可致无菌性腹膜炎。ObjectiveThe paper reports the histopathological changes on aseptic peritonitis in SD rat induced by inject-ing solvent of 40% alcohol intraperitoneally.MethodsThe visceras of SD rat were rapidly removed and fixed in 11% for-malin,embedded in paraffin after routine dehydration and transparency,sectioned at a thickness of 5μm and stained with hematoxyline and eosin(HE),and examined by light microscopy.Resultsperitonitis has not taken place in the normal rats,more serious peritonitis has taken place in the gr...

关 键 词：大鼠 腹膜炎 形态学改变 

分 类 号：R572.2[医药卫生—消化系统]