染料木素、槲皮素及其化学修饰物清除自由基能力研究  

Free Radical Scavenging Activity of Genistein and Quercetin and Their Derivatives

作　　者：胡昕[1] 余燕影[1] 李华[1] 曹树稳[2] 尹文斌[3] 

机构地区：[1]南昌大学化学系 [2]南昌大学食品科学教育部重点实验室,南昌330047 [3]南昌市工业技术研究院,南昌330006

出　　处：《天然产物研究与开发》2008年第2期203-206,共4页Natural Product Research and Development

基　　金：国家自然科学基金(20562008);长江学者和创新团队发展计划(IRT0540)项目

摘　　要：分别采用Fenton反应-邻菲罗啉显色法、邻苯三酚自氧化法和紫外可见分光光度法,考察染料木素、槲皮素及其化学修饰物清除·OH、·O2-和DPPH自由基能力。结果显示,槲皮素铬配合物清除·OH、·O2-和DPPH自由基能力大大高于其母体槲皮素,同时,其稳定性和抗自氧化的能力亦得到提高;染料木素铬配合物清除·OH和·O2-自由基的能力高于其母体染料木素,其清除.OH自由基的能力提高最为显著;染料木素糖苷修饰物清除三种自由基能力与其母体相比无显著提高。因此,染料木素铬和槲皮素铬配合物是一类高活性、高稳定性自由基清除剂或与自由基相关疾病新药的候选物,值得进一步研究。The abilities of genistein and quercetin and their derivatives in free radical scavenging of ·OH and·O2-and DPPH were exploited by using Fenton reaction with O-phenanthroline chromogenic reaction,pyrogallol autoxidation method and UV-vis spectrophotometry,respectively.The results show that the abilities of quercetin-Cr complex in scavenging of the three free radicals were much stronger than those of quercetin.At the same time,the stability and anti-autoxidation ability of quercetin-Cr complex were also impr...

关 键 词：染料木素 槲皮素 化学修饰物 自由基清除 

分 类 号：R285[医药卫生—中药学]