超量焦亚硫酸钠摄入对小鼠腹腔巨噬细胞功能的影响  

Toxic effect of sodium pyrosulfite on peritoneal macrophage of mice

作　　者：马全祥[1] 毛泽善[1] 袁向山[1] 韩金珠[1] 

机构地区：[1]新乡医学院组织胚胎学教研室,新乡453003

出　　处：《陕西医学杂志》2007年第2期134-136,共3页Shaanxi Medical Journal

基　　金：河南省自然科学基金项目资助(004012300)

摘　　要：目的:研究超量摄入焦亚硫酸钠对小鼠免疫功能的影响。方法:将40只小鼠随机平分为对照组和实验组,对照组用静置后的自来水喂食,实验组用1%的焦亚硫酸钠喂食,10d后检测2组小鼠腹腔巨噬细胞内酸性磷酸酶活性的变化以及巨噬细胞吞噬功能的变化。结果:与对照组相比,实验组小鼠腹腔巨噬细胞内酸性磷酸酶活性明显下降,巨噬细胞的吞噬功能下降。结论:1%焦亚硫酸钠对小鼠的免疫功能有抑制作用。Objective:To research the Toxic effect of sodium pyrosulfite on peritoneal macrophage of Mice.Methods:Forty mice were equally divided into control group and experimental group.The control group were fed with water and the experimental group with 1% sodium pyrosulfite for 10 days,then detected the changes of acid phosphatase(ACP)activity in peritoneal macrophage(PMΦ)and the engulfing function of PMΦ were detected.Results:Compared to control group,the ACP activity of PMΦ deteriorated in experimental group and the engulfing function of PMΦ deteriorated too.Conclusion:It is indicated that toxic effect on immunological function in mice can be caused by feeding 1% Sodium Pyrosulfite.

关 键 词：巨噬细胞/免疫学 酸性磷酸酶/分析 @焦亚硫酸钠 

分 类 号：R[医药卫生]