阿奇霉素在中国健康人体血浆中的药动学研究  

Pharmacokinetics in Plasma of Azithromycin Tablet in Chinese Healthy Volunteers by HPLC-UV

作　　者：张雁[1] 李东[2] 王大果[2] 朱永泉[2] 

机构地区：[1]深圳市孙逸仙心血管医院,广东深圳518001 [2]暨南大学第二临床医学院,深圳市人民医院临床药学研究室,广东深圳518020

出　　处：《中国现代应用药学》2007年第z1期601-604,共4页Chinese Journal of Modern Applied Pharmacy

基　　金：深圳市卫生科技计划项目;项目编号:200006018

摘　　要：目的研究阿奇霉素在健康中国人体中的血浆药动学,为临床用药提供参考。方法10名健康志愿者单剂量口服阿奇霉素500mg后,高效液相色谱-紫外检测法测定血浆药物浓度。采用F检验结合AIC法判别房室模型,DAS药动学程序计算药动学参数。结果最佳房室模型为二室模型(Wi=1/C2,AICmin=-7.4821),主要的药动学参数:α为(0.29±0.13)h-1,β为(0.02±0.003)h-1,Ka为(0.72±0.22)h-1,t1/2β为(38.93±7.74)h,tmax为(2.60±0.49)h,cmax为(434.74±47.65)μg.L-1,AUC0～144和AUC0～∞分别为(12179.42±3001.11)μg.h.L-1和(13338.35±3062.56)μg.h.L-1。结论阿奇霉素片在中国健康人体中的血浆药动学参数与国内外文献报道基本一致。OBJECTIVE To study the pharmacokinetics of azithromycin tablet in Chinese healthy volunteers.METHODS 10 healthy volunteers were given a single oral dose of 500mg azithromycin tablet.The plasma concentrations of azithromycin were determined by HPLC-UV.The compartment model was fitted by F test and AIC method and the pharmacokinetic parameters were calculated by DAS program.RESULTS The pharmacokinetics was best fitted to a two-compartment model(Wi=1/C2,AICmin=-7.4821).The main pharmacokinetic parameters of azithromycin for orally administered tablet were as follows:α(0.29±0.13)h-1,β(0.02±0.003)h-1,Ka(0.72±0.22)h-1,t1/2β(38.93±7.74)h,tmax(2.60±0.49)h,cmax(434.74±47.65)μg·L-1,AUC0~144(12179.42±3001.11) μg·h·L-1 and AUC0~∞(13338.35±3062.56) μg·h·L-1.CONCLUSION The pharmacokinetic parameters of azithromycin tablet in Chinese healthy volunteers are similar to that of foreign report.

关 键 词：阿奇霉素 HPLC-UV 血浆 药动学 

分 类 号：R916.695[医药卫生—药学]