洗液一号主要药效学及皮肤毒性的实验研究  

An Experimental Study on Main Pharmacodynamics and Dermal Toxicity of Washings-1

作　　者：李顺英[1] 张晓冬[1] 陈彦清[2] 赵永娜[1] 张肇玖[1] 

机构地区：[1]昆明医学院,云南昆明650031 [2]四川省攀枝花市中心医院,四川攀枝花617067

出　　处：《云南中医中药杂志》2007年第6期38-40,共3页Yunnan Journal of Traditional Chinese Medicine and Materia Medica

摘　　要：目的:观察洗液一号抑菌、抗炎、止痒的药理作用及安全性。方法:液体试管抑菌、小鼠耳廓二甲苯致炎、大鼠角叉菜胶足跖肿胀、磷酸组织胺致痒、皮肤急性毒性、长期毒性、过敏、皮肤及粘膜刺激等实验。观察洗液一号的最小抑菌浓度、止痒、抗炎的药理作用及皮肤粘膜毒性。结果:洗液一号对多种常见阴道炎致病菌具抑制作用,能抑制二甲苯所致的小鼠耳廓肿胀及角叉菜胶所致的大鼠足跖肿胀,能明显提高豚鼠致痒阈,未发现皮肤粘膜毒性。结论:洗液一号具有抑菌、抗炎、止痒作用且安全。Objective: To observe the bacteriostasis、antipruritic and anti-inflammatory effects and safety of Washing-1.Method: Bacteriostasis by solution in test tube、auricular intumesce of mice induced by dimethylbenzene、toe intumesce of rats induced by carrageenin、itch caused by histamine phosphate、acute skin toxicity、long-term toxicity、hypersensitiveness、skin and mucous membrane stimulus and so forth were made to observe the minimum inhibition concentration(MIC)、the antipruritic、anti-inflammatory effect and toxicity in skin and mucous membrane of Washing-1.Result: Washing-1 could inhibit diverse frequent pathogenic bacteriums of coleitis,relieve the auricular intumesce of mice induced by dimethylbenzene and the toe intumesce of rats induced by carrageenin and significantly elevate the itch threshold of guinea pigs.No skin and mucous membrane toxicity of Washing-1 was found.Conclusion:Washing-1 has the effects of bacteriostasis、antipruritic and anti-inflammatory and can be used safely.

关 键 词：洗液一号 阴道炎 抑菌 抗炎 止痒 皮肤毒性 

分 类 号：R285.5[医药卫生—中药学]