GC-MS检测大鼠尿液中曲马多及其代谢产物  

Determination Tramadol and Its Metabolites in Urine by GC-MS

作　　者：黄克建[1] 潘智文[2] 李宏森[1] 林翠梧[2] 刘晓锋[1] 李璐[1] 罗正坚[1] 

机构地区：[1]广西区公安厅物证鉴定中心,广西南宁530012 [2]广西大学化学化工学院,广西南宁530004

出　　处：《分析测试学报》2007年第z1期89-92,共4页Journal of Instrumental Analysis

摘　　要：Tramadol and its four metabolites O-desmethyltramadol,N-desmethyltramadol,N,O-didesmethyltramadol,Hydroxy tramadol were identified by GC-MS(EI,PCI).The contents and kinds of tramadol and its metabolites were compared between human urine and rat urine.The identical metabolites were found in human urine and rat urine but different contents.Some of the tramadol and its metabolites existing as conjugative and the others existing as educts in body were found after enzymatic hydrolysis.Tramadol and its four metabolites O-desmethyltramadol,N-desmethyltramadol,N,O-didesmethyltramadol,Hydroxy tramadol were identified by GC-MS(EI,PCI).The contents and kinds of tramadol and its metabolites were compared between human urine and rat urine.The identical metabolites were found in human urine and rat urine but different contents.Some of the tramadol and its metabolites existing as conjugative and the others existing as educts in body were found after enzymatic hydrolysis.

关 键 词：TRAMADOL METABOLITES URINE GC-MS 

分 类 号：O657-55[理学—分析化学]