胃肠道间质瘤27例临床病理分析  

Pathological Analysis of 27 Cases with Gastrointestinal Stromal Tumors in Qinghai Region

作　　者：吴彩虹[1] 周世英[1] 咸文娟[1] 

机构地区：[1]青海省人民医院病理科,810007

出　　处：《青海医药杂志》2007年第8期12-15,共4页Qinghai Medical Journal

摘　　要：目的:研究胃肠道间质瘤(GISTs)的临床病理及免疫组织化学特征。方法:分析27例GISTs患者的临床病理资料,使用免疫组织化学方法检测Vimentin、CD117、CD34、SMA和S-100的表达。结果:GISTs主要发生在胃(55.6%)和小肠(18.5%),瘤细胞Vimentin、CD117和CD34阳性率分别为92.6%、85.2%、70.4%,部分病例SMA、S-100呈阳性。良性、潜在恶性和恶性组之间在肿瘤直径、核分裂相数上的差别有统计学意义。结论:GISTs是胃肠道最常见的间叶性肿瘤;CD117和CD34标记阳性是确诊GISTs最有价值的诊断依据;判断肿瘤的恶性程度可参考肿瘤直径大小、核分裂相数等指标。Objective:To observe the pathological and immunohistochemical features of gastrointestinal stromal tumors(GISTs).Methods:The pathological data of 27 patients with GISTs were analyzed retrospectively.Expressions of Vimentin,CD117,CD34,SMA and S-100 were determined by the immunohistochemistry.Results: GISTs were generally found in the stomach(55.6%) or small intestine(18.5%).Expressions of Vimentin,CD117 and CD34 were 92.6%,85.2% and 70.4% respectively.SMA and S-100 expressed in partial GISTs.There were significant differences in tumour diameter and mitotic activity among benign,potential malignant and malignant GISTs.Conclusions: GISTs is the most common tumor in gastrointestinal mesenchymal tumors.The expressions of CD117 and CD34 are the most valuable factors for diagnosis of gastrointestinal stromal tumors.Tumor's diameter and mitotic activity can be used as malignant parameters in clinic.

关 键 词：胃肠道间质瘤 临床病理 免疫组织化学 

分 类 号：R735[医药卫生—肿瘤]