颈动脉粥样硬化患者认知功能与事件相关电位的改变及其关系  

Changes and their relationship between cognitive function and event-related potentials in patients with carotid atherosclerosis

作　　者：王蓓[1] 李慧[1] 徐蓓[1] 时恒屏[1] 王海风[1] 颜怀新[2] 

机构地区：[1]江苏省连云港市第一人民医院神经内科,222002 [2]江苏省连云港市第一人民医院B超室,222002

出　　处：《临床神经病学杂志》2007年第5期334-336,共3页Journal of Clinical Neurology

摘　　要：目的探讨颈动脉粥样硬化(CAS)患者认知功能与事件相关电位(ERP)的改变及其关系。方法对65例不同程度CAS患者进行简易精神状态检查量表(MMSE)和ERPP300检查及相关性分析;并与对照组进行比较。结果与对照组比较,轻中度CAS组的注意计算、短程记忆、图形描画评分明显降低(均P<0.05);P300潜伏期延长、波幅降低(均P<0.05);重度CAS组差异更明显(均P<0.01)。与轻中度颈动脉狭窄组比较,重度颈动脉狭窄组在时间定向力、地点定向力、注意计算、短程记忆、言语复述、语言表达、图形描画7个亚项评分方面有显著降低(均P<0.05);P300潜伏期延长、波幅降低(均P<0.05)。轻中度、重度CAS患者的MMSE评分与P300潜伏期呈负相关(r=-0.503,-0.589,均P<0.05),轻中度、重度颈动脉狭窄患者的MMSE评分与P300潜伏期亦呈负相关(r=-0.497,-0.601,均P<0.05)。结论CAS可导致认知功能障碍和ERP异常,其程度与颈动脉病变程度有关。Objective To investigate the changes and their relationship between cognitive function and event-related potentials(ERP)in patients with carotid atherosclerosis.Methods 65 patients with varying degrees of carotid atherosclerosis were carried out Mini-Mental State Examination(MMSE)and Frederick ERP P300 investigation and correlation analysis was done,compared with the control group.Results Compared with the control group,account ability,short-term memory and graphics portrayed score decreased in mild and moderate carotid atherosclerosis group(all P<0.05),P300 latency extension and amplitude decreased(all P<0.05).The group of severe carotid atherosclerosis more obvious difference compared with the control group(all P<0.01).Compared with mild and moderate carotid stenosis group,the scores of time orientation,place orientation,account ability,short-term memory,language repetition,language expression and graphic portrayed were significantly lower in group of severe stenosis(all P<0.05).P300 latency extension and amplitude decreased in group of severe stenosis(all P<0.05).MMSE score was negatively correlated with P300 latency in patients with mild,moderate and severe carotid atherosclerosis(r=-0.503,-0.589,all P<0.05),MMSE score was also negative correlation with P300 latency in patients with mild,moderate and severe carotid artery stenosis(r=-0.497.-0.601,all P<0.05).Conclusion Carotid atherosclerosis can lead to cognitive dysfunction and abnormal ERP,and its extent is related to the degree of carotid artery stenosis.

关 键 词：颈动脉粥样硬化 认知功能 事件相关电位 

分 类 号：R743.1[医药卫生—神经病学与精神病学]