脉搏波速度与冠状动脉粥样硬化的关系  

The Relationship Between Pulse Wave Velocity and Coronary Atherosclerosis

作　　者：曲娜[1] 刘晓方[1] 王淑霞[1] 

机构地区：[1]宁夏医学院附属医院心内科,宁夏银川市750004

出　　处：《中国动脉硬化杂志》2007年第3期217-220,共4页Chinese Journal of Arteriosclerosis

摘　　要：目的为探讨脉搏波速度与冠状动脉粥样硬化程度的关系。方法本文选择行冠状动脉造影或介入治疗的患者104例,进行脉搏速度测量、血液生化检查、病史采集及冠状动脉造影。结果年龄、脉搏速度、脉压是显著性影响冠脉病变的危险因素(P<0.05);年龄、脉搏速度、高血压病史、收缩压、脉压、吸烟、胆固醇在冠状动脉病变程度组间差异有显著性(P<0.05);年龄、脉搏速度、脉压、总胆固醇、吸烟在多支病变组与正常组之间差异有显著性(P<0.05)。按照冠状动脉病变最大狭窄程度分组,冠状动脉病变程度间脉搏速度有显著性差异(P<0.05);狭窄1级、2级、3级、4级与0级,狭窄1级与2级脉搏速度比较差异有显著性(P<0.05)。按脉搏速度值≤14m/s和>14m/s分组,两组患者冠状动脉病变严重程度差异有显著性(P<0.05);脉搏速度>14m/s组的患者既往多数有高血压病史,3支血管病变在脉搏速度>14m/s组中显著增高;冠状动脉无病变者在脉搏速度≤14m/s组中显著性增多。冠心病合并高血压组与未合并高血压组患者的脉搏速度间差异有显著性意义(P<0.05)。在年龄与体重指数无明显差异的条件下,冠心病组、冠心病合并糖尿病组、冠心病合并高血压组、冠心病合并高血压及糖尿病组脉搏速度值逐渐升高(P<0.05);冠心病组患者随着病变支数的增多,脉搏速度值显著性升高(P<0.05)。结论提示脉搏速度与冠状动脉病变严重程度呈显著相关性,脉搏速度可综合反映高血压、高血糖等危险因素对血管的损伤,更能精确地对患者进行心血管危险分层,它可作为对冠心病患者危险分层的评估和冠状动脉严重程度识别的独立因素。Aim To discuss the relationship between the pulse wave velocity and coronary atherosclerosis. Methods 104 patient were selected, all patients were underwent coronary arteriongraphy or interventional therapy, and pulse wave velocity, blood biochemistry examination, history-taking were measured to analyze the serious degree relationship between pulse wave velocity and coronary artery disease. Results Age and PWV and pulse pressure were significant risk factor of coronary atherosclerosis. Age, PWV, pulse pressure, hypertensive history systolic blood pressure, smoking and cholesterol have significant difference in coronary artery disease extent. According to the grouping of largest narrow degree of coronary artery disease, there is significant difference between narrow degree 1, 2, 3, 4 and 0 in severity of coronary heart disease; between narrow degree 1 and 2 there is significant difference. Comparing patients with PWV≤14.02 m/s and PWV>14 m/s, there is significant difference in severity ofcoronary artery. Patients with PWV>14 m/s had higher incidence of 3 disease. There is no difference between patients with essential hypertension and those without hypertensios. PWV may reflect kinds of risk factor to vascul damages. Conclusions There are dependablities about PWV and coronary artery disease severity degree. Detecting PWV can be used to evaluate the coronary artery disease danger hierarchication,and it can identify the coronary artery severity extent.

关 键 词：内科学 全自动动脉硬化测定 冠状动脉粥样硬化 冠状动脉造影 脉搏波速度 危险分层 

分 类 号：R363[医药卫生—病理学]