氧化苦参碱联合二甲双胍对非酒精性脂肪肝患者胰岛素抵抗及血清TNFα的影响  

Clinical effect of oxymatrine combined with metformin on insulin resistance and serum TNF-α in patients with non-alcoholic fatty liver

作　　者：余小虎[1] 朱金水[2] 顾国妹[1] 施建平[1] 

机构地区：[1]上海市南汇区中心医院,上海201300 [2]上海交通大学附属第六人民医院,上海200233

出　　处：《临床肝胆病杂志》2007年第3期195-196,共2页Journal of Clinical Hepatology

摘　　要：分析氧化苦参碱联合二甲双胍对非酒精性脂肪肝患者胰岛素抵抗及血清TNFα等的影响。非酒精性脂肪肝患者48例,分为两组,试验组24例联合服用氧化苦参碱及二甲双胍,对照组24例服用氧化苦参碱和维生素C,疗程均为6月。治疗前后测定血清转氨酶水平、血清TNFα水平、胰岛素抵抗指数(IR I)及肝/脾CT比值,同时观察不良反应。治疗后试验组血清ALT、胰岛素抵抗指数、血清TNFα与对照组相比均明显下降(P<0.05),同时试验组治疗后肝/脾CT比值较对照组显著升高(P<0.01)。氧化苦参碱联合二甲双胍对非酒精性脂肪肝有显著疗效且用药安全,其作用机理可能与胰岛素抵抗指数及血清TNFα水平的下降有关。To assess the therapeutic effect of oxymatrine combined with metformin on insulin resistance index and serum TNF-α in patients with non-alcoholic fatty liver.48 patients with non-alcoholic fatty liver were randomly divided into experiment group treated with oxymatrine combined with metformin(n=24) and control group treated with oxymatrine combined with vitamin c(n=24) for consecutive 4-6 months.Serum transaminaswe level(ALT,AST),TNF-α,insulin resistance index(IRI) and liver/spleen CT index were detected before and after treatment respectively.All data were processed with statistics.The levels of serum ALT in experiment group were obviously reduced at the end point compared with those of control group(P<0.05).The levels of IRI and serum TNF-alpha in experiment group were all significantly decreased at the end point compared with those of control group(P<0.05).Meanwhile,liver/ spleen CT index in experiment group were obviously increased after treatment compared with that of control group(p<0.01).And no severe side-effects occurred during the experiment.Oxymatrine combined with metformin was an effective and safe remedy for treating on non-alcoholic fatty liver.The mechanism might be related to the reduction of IRI and serum TNF-TNF-α.

关 键 词：氧化苦参碱 二甲双胍 非酒精性脂肪肝 胰岛素抵抗 肿瘤坏死因子-α 

分 类 号：R575.5[医药卫生—消化系统]