依达拉奉对急性脑梗死的神经保护作用  

Neurological protection effect of edaravone on acute cerebral infarction

作　　者：李检生[1] 代红源[1] 董巍[2] 余能伟[1] 董凌琳[1] 杨友松[1] 

机构地区：[1]四川省人民医院神经内科,四川成都610072 [2]四川省人民医院临床中心实验室,四川成都610072

出　　处：《实用医院临床杂志》2008年第2期41-43,共3页Practical Journal of Clinical Medicine

摘　　要：目的评价依达拉奉的神经保护作用及对患者临床预后的影响。方法38例急性脑梗死患者采用随机对照双盲试验,分别使用依达拉奉或安慰剂,于用药前、用药后第7天、14天、21天检测血清超氧化物歧化酶(T-SOD)、丙二醛(MDA)、神经特异性烯醇(NSE),并评价神经功能缺损(NDS)和日常生活能力(ADL)。结果试验组与对照组T-SOD均呈上升趋势,两组比较差异无显著性意义(P>0·05);两组MDA均呈下降趋势,试验组明显大于对照组(P<0·05);两组NSE均呈下降趋势(P>0·05);试验组在第7天、14天、21天、3月的NDS和ADL评分与对照组比较,在第14天、21天差异最明显(P<0·001)。结论依达拉奉可能具有降低血清MDA及改善神经功能和提高日常生活能力的作用。ObjectiveTo evaluate the effect of Edaravone on nerve cells and the prognosis of acute cerebral infarction. MethodsThirty-eight cases of cerebral infarction were divided into trial (Edaravone) group and placebo group. Serum superoxide (SOD), malondialdehytde (MDA) and neurone specific enolase (NSE) were assessed. The neurologic disfuction and the activity of daily living at 1, 7,14, and 21 days were assessed. ResultsThe levels of MDA were declined in both groups, but the medication group had a more apparent...

关 键 词：依达拉奉 脑梗死 随机双盲对照 神经保护 

分 类 号：R743.3[医药卫生—神经病学与精神病学]