抑郁症患者细胞因子与甲状腺激素的研究  

A Study on Relationship between Cytokines and Thyraid Hormone in Patients with Depression

作　　者：莫煊[1] 党海红[2] 邹韶红[1] 曾建梅[1] 

机构地区：[1]新疆维吾尔自治区人民医院临床心理科,中国乌鲁木齐市830001 [2]新疆医科大学第一附属医院心身科

出　　处：《中国健康心理学杂志》2008年第4期431-433,共3页China Journal of Health Psychology

摘　　要：目的探讨抑郁症与细胞免疫功能及甲状腺功能的关系。方法采用酶联免疫吸附法(ELSIA)检测39例抑郁症患者血清IL-2、IL-6、INF-α水平;采用放射免疫法检测血清总T3、T4、TSH。同时以38名健康者作为对照组进行病历对照研究。结果抑郁症组血清IL-2、IL-6,T4浓度比对照组高,抑郁症组TSH浓度比对照组低,差异有统计学意义(P<0.01,P<0.05)。抑郁症组与对照组血清INF-α,T3浓度差异无统计学意义(P>0.05)。结论抑郁症患者血清细胞因子浓度(IL-2,IL-6)升高,存在免疫激活。抑郁症的病因和发病机制存在免疫及内分泌方面的异常。Objective To investigate the relationship between thyroid function and cytokines in depression patients.Methods 39 patients with depression and 38 healthy controls were collected.Blood samples were adopted for the radioimmunity assay of thyroid function and enzyme-linked immuno-sorbent assay of IL-2,IL-6 and INF-α.Results There are significant differences in plasma levels of IL-2 and IL-6,but no significant difference of INF-α between the two groups.Total T4 level is significantly higher in depression patie...

关 键 词：抑郁症 甲状腺激素 细胞因子 

分 类 号：R749.4[医药卫生—神经病学与精神病学]