急性髓系白血病免疫表型分析及其临床意义研究  

Study on clinical significance of immunophenotype characteristics in acute myeloid leukemia

作　　者：陈晨[1] 杨宪勇[2] 滕清良[2] 时昊[3] 

机构地区：[1]泰山医学院,山东泰安271016 [2]泰山医学院附属泰安医院血液科,山东泰安271000 [3]泰山医学院附属医院血液科,山东泰安271000

出　　处：《泰山医学院学报》2008年第2期100-103,共4页Journal of Taishan Medical College

摘　　要：目的探讨急性髓系白血病(AML)免疫表型特征及其临床意义。方法采用流式细胞术(FCM)随机检测44例AML患者骨髓单个核细胞髓系和淋巴系免疫标志物,分析免疫标志物在AML的表达情况;根据淋巴系抗原髓系抗原的共表达情况,将AML分为淋巴系抗原阳性AML(Ly+AML)和淋巴系抗原阴性AML(Ly-AML),对二组AML采用统一方案化疗,比较二组AML化疗疗效。结果(1)44例AML中32例单纯表达髓系抗原,分别为CD13 86.4%,CD14 34.1%,CD15 36.4%。12例同时表达髓系、淋巴系抗原,其中,CD7+6例,CD10+2例,CD19+2例,CD3+1例,CD5+1例。(2)Ly+AML组的化疗的完全缓解率(CR)低于Ly-AML组(P<0.05)。结论免疫分型对于AL的分型诊断及其预后判断均有重要的指导意义。Ly+AML疗效差。Objective:To explore the immunophenotype characteristics and its clinical significance in acute myeloid leukemia(AML).Methods: Flow cytometry(FCM) was used to detect the bone marrow mononuclear cells(BMMNCs) of 44 patients with AML,and the antigens expression in AML was analyzed.The patients with AML were divided into the two groups: AML with positive lymphoid antigen(Ly+AML)and AML with negative expression of lymphoid antigen(Ly-AML), and all the cases were treated by unified protocol for chemotherapy,and ...

关 键 词：急性髓系白血病 免疫表型 流式细胞术 

分 类 号：R733.7[医药卫生—肿瘤]