星状神经节阻滞对心肌梗死兔的心肌保护作用  

Myocardial protective effects of stellate ganglion block on myocardial infarction in rabbits

作　　者：王颖[1] 张克呈[2] 李耀纬[1] 陈静[1] 

机构地区：[1]河北大学附属医院麻醉科,保定071000 [2]河北大学医学部解剖教研室

出　　处：《陕西医学杂志》2008年第6期657-659,共3页Shaanxi Medical Journal

摘　　要：目的:评价星状神经节阻滞(SGB)对兔实验性心肌梗死的影响。方法:取日本大耳白兔30只,随机分为3组。A组行右侧SGB,B组行左侧SGB,C组为对照组。于阻滞后3组均开胸结扎冠状动脉左前降支,不同时点抽取颈外静脉血测定肌钙蛋白I。采血完毕后,将实验兔处死,沿冠状沟剪取心室,冲去心腔内积血,并用滤纸吸干,称取心室湿重,冷冻10min(便于切片)取出,将心室横切成5片(每片约5mm),放入新鲜配置的盐酸硝基四氮唑蓝(N-BT)溶液中,在37℃恒温水浴中保温30min。染色完毕,切除正常心肌组织,将未染色区称重,计算梗死心肌占心室重的百分比,以判断梗死范围。各组随机选取兔在结扎动脉供血区取心肌组织,在光镜和电镜下观察心肌细胞损伤程度。结果:结扎后各组生化结果及病理变化呈心肌梗死表现,各时点A、B组肌钙蛋白I的升高显著低于C组(P<0.05),A、B组心肌梗死范围明显少于C组,光镜和电镜下A、B组心肌梗死程度较轻。结论:星状神经节阻滞对心肌梗死兔心肌具一定保护作用。Objective:To investigate the protective effects of SGB on experimental myocardial infarction.Methods:30 japanese white rabbits,were randomly divided into three groups:the right SGB group A,the left SGB group B and the control group C.After completing the SGB operation,the left anterior descending coronary was ligated under the first branch at the outset of the left coronary artery.The blood sample was taken from the external jugular vein of each group pre-ligation,post-ligation 1,2 and 4 hours.The Cardiac T...

关 键 词：心肌梗塞/预防与控制 星状神经节 阻断疗法 

分 类 号：R542.22[医药卫生—心血管疾病]